Table 2 Univariate and multivariate analysis of overall survival

Tumor depth (2, 3, 4 vs. 1)

2.43

1.56–4.27

0.004

2.01

1.49–2.78

<0.001

Nodal status (yes vs. no)

3.41

2.25–5.39

0.001

0.001

2.59–4.63

<0.001

Distant metastasis (yes vs. no)

5.56

3.52–9.54

<0.001

4.02

3.72–8.17

<0.001

LVI (yes vs. no)

2.68

1.84–5.39

0.001

2.32

1.35–3.51

0.001

Differentiation (poor vs. well/mod)

2.29

1.32–3.54

0.005

1.78

0.85–2.39

0.307

Preop. CEA (>5 ng/ml vs. <5 ng/ml)

2.87

1.95–4.35

<0.001

2.32

1.45–4.24

0.001

Loss expression of PTEN (yes vs. no)

1.28

0.65–4.52

0.372

1.12

0.87–2.27

0.433

PTEN hypermethylation (yes vs. no)

1.32

0.76–3.51

0.253

1.07

0.73–1.89

0.527

PTEN DNA copy number (high vs. low)

1.11

0.67–2.34

0.652

1.13

0.66–1.78

0.487

Mucinous histology (yes vs. no)

0.96

0.29–3.13

0.949

Location (rectum vs. colon)

0.75

0.39–1.47

0.406

Gender (male vs. female)

0.97

0.51–1.86

0.942