Figure 5
From: let-7b and let-7c are determinants of intrinsic chemoresistance in renal cell carcinoma
Knockdown of Akt2 enhanced the chemosensitivity through caspase-7. (A) Relative cell survival of 786-O cells 48 h after transfected with Akt2 siRNA and treated with 5-FU. Proliferation of 786-O cells after transfection of Akt2 siRNA was significantly reduced compared with negative control (*P < 0.05). (B) Akt2 and caspase-7 protein levels were assessed by Western blot in 786-O cells transfected with si-Akt2 (#1, #2) and negative control. Akt2 knockdown showed the increased expression of caspase-7.