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Table 1 Clinicopathological features of 17 cases of large-cell neuroendocrine carcinoma of the gallbladder

From: Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature

Number

Author [ref.]

Gender/ age

Presentation

Tumor location

Tumor size (cm)

Liver invasion

Metastasis

Other component

Treatments

Prognosis, follow-up (month)

1

Papotti et al. [3]

M/50

Unclear

Unclear

<1

-

-

AC

Cho

DFS, 12

2

Papotti et al. [3]

M/65

Unclear

Fundus

2.5

-

Liver

-

Cho

Died, 14

3

Jun et al. [4]

M/55

AP, jaundice

Unclear

Unclear

Unclear

Lymph node

-

Needle biopsy, Che

Died, 1

4

Jun et al. [4]

F/67

AP

Unclear

Huge

+

Lymph node

-

Needle biopsy, Che

Died, 10

5

Noske and Pahl [5]

F/81

AP, jaundice

Neck

5

+

Bone

Adenosquamous

Palliative surgery

Unknown

6

Oshiro et al. [6]

F/55

Back pain, fever

Body

4.9

-

-

AC, SCNEC

Radical Cho

DFS, 20

7

Shimono et al. [7]

F/64

AP

Unclear

11.5

+

-

-

Che, Rad, extended hepatectomy

DFS, 36

8

Iype et al. [8]

M/85

Anorexia, weight loss

Fundus

1.5

-

Unclear

AC

Cho, Che

Died, 21

9

Lin et al. [9]

F/65

Cushing’s syndrome

Body

Unclear

-

-

-(ACTH-producing)

Radical Cho, Che

Died, 2

10

Sato et al. [10]

F/68

Negative

Fundus

3

+

Lymph node

AC

Cho, extended hepatectomy

DFS, 12

11

Paniz et al. [11]

F/48

AP

Fundus

3.5

+

Unclear

AC

Cho, extended hepatectomy

Unknown

12

Al-Brahim and Albannai [12]

M/45

AP, jaundice

Fundus

5.7

+

Unclear

AC

Cho, Che

Unknown

13

Okuyam et al. [13]

M/64

Abdominal fullness

Fundus

2.5

+

Lymph node

-

Biopsy, Che

Died, 22

14

Nakagawa et al. [14]

M/56

Exophthalmos

Unclear

9

+

Multiple

AC

Che, Rad

Died, 36

15

Meguro et al. [15]

F/54

Negative

Unclear

Unclear

-

-

AC

Cho, extrahepatic bile duct resection

DFS, 24

16

Russo et al. [16]

M/59

AP

Body

4

+

Lymph node

Mucinous carcinoma

Radical Cho

Unknown

17

Current study, 2014

F/63

AP, fever

Body

2.0

-

-

AC

Radical Cho

DFS, 12

  1. AP, abdominal pain; AC, adenocarcinoma; ACTH, adrenocorticotropic hormone; Che, chemotherapy; Cho, cholecystectomy; DFS, disease-free survival; F, female; M, male; Rad, radiotherapy; SCNEC, small-cell neuroendocrine carcinoma.