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Table 1 Clinicopathological features of 17 cases of large-cell neuroendocrine carcinoma of the gallbladder

From: Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature

Number Author [ref.] Gender/ age Presentation Tumor location Tumor size (cm) Liver invasion Metastasis Other component Treatments Prognosis, follow-up (month)
1 Papotti et al. [3] M/50 Unclear Unclear <1 - - AC Cho DFS, 12
2 Papotti et al. [3] M/65 Unclear Fundus 2.5 - Liver - Cho Died, 14
3 Jun et al. [4] M/55 AP, jaundice Unclear Unclear Unclear Lymph node - Needle biopsy, Che Died, 1
4 Jun et al. [4] F/67 AP Unclear Huge + Lymph node - Needle biopsy, Che Died, 10
5 Noske and Pahl [5] F/81 AP, jaundice Neck 5 + Bone Adenosquamous Palliative surgery Unknown
6 Oshiro et al. [6] F/55 Back pain, fever Body 4.9 - - AC, SCNEC Radical Cho DFS, 20
7 Shimono et al. [7] F/64 AP Unclear 11.5 + - - Che, Rad, extended hepatectomy DFS, 36
8 Iype et al. [8] M/85 Anorexia, weight loss Fundus 1.5 - Unclear AC Cho, Che Died, 21
9 Lin et al. [9] F/65 Cushing’s syndrome Body Unclear - - -(ACTH-producing) Radical Cho, Che Died, 2
10 Sato et al. [10] F/68 Negative Fundus 3 + Lymph node AC Cho, extended hepatectomy DFS, 12
11 Paniz et al. [11] F/48 AP Fundus 3.5 + Unclear AC Cho, extended hepatectomy Unknown
12 Al-Brahim and Albannai [12] M/45 AP, jaundice Fundus 5.7 + Unclear AC Cho, Che Unknown
13 Okuyam et al. [13] M/64 Abdominal fullness Fundus 2.5 + Lymph node - Biopsy, Che Died, 22
14 Nakagawa et al. [14] M/56 Exophthalmos Unclear 9 + Multiple AC Che, Rad Died, 36
15 Meguro et al. [15] F/54 Negative Unclear Unclear - - AC Cho, extrahepatic bile duct resection DFS, 24
16 Russo et al. [16] M/59 AP Body 4 + Lymph node Mucinous carcinoma Radical Cho Unknown
17 Current study, 2014 F/63 AP, fever Body 2.0 - - AC Radical Cho DFS, 12
  1. AP, abdominal pain; AC, adenocarcinoma; ACTH, adrenocorticotropic hormone; Che, chemotherapy; Cho, cholecystectomy; DFS, disease-free survival; F, female; M, male; Rad, radiotherapy; SCNEC, small-cell neuroendocrine carcinoma.