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Table 3 Age at diagnosis in relation to breast cancer-specific mortality with stratification for axillary lymph node status

From: Age at diagnosis in relation to survival following breast cancer: a cohort study

Axillary lymph node status Age at diagnosis (years) Subjects Person-years Breast cancer deaths (all deaths) Breast cancer mortality/10,000 a Relative risk (95% CI) Relative risk b (95% CI) Relative risk c (95% CI)
Negative 5- year follow-up <40 84 399 11 (12) 276 2.65 (1.23-5.70) 2.40 (1.11-5.17) 1.91 (0.88-4.19)
   40-49 313 1,531 16 (23) 105 1.00 1.00 1.00
   50-59 434 2,052 32 (48) 156 1.50 (0.82-2.73) 1.68 (0.92-3.06) 1.64 (0.90-3.02)
   60-69 579 2,761 29 (65) 105 1.01 (0.55-1.86) 0.92 (0.49-1.71) 0.87 (0.46-1.64)
   70-79 373 1,661 29 (81) 175 1.70 (0.92-3.12) 1.50 (0.81-2.80) 1.35 (0.71-2.58)
   ≥80 123 488 10 (57) 205 2.03 (0.92-4.47) 1.69 (0.76-3.78) 1.88 (0.82-4.30)
   All 1,906 8,890 127 (286) 143    
  10-year follow-up <40 84 741 15 (18) 202 1.69 (0.92-3.09) 1.53 (0.84-2.81) 1.29 (0.70-2.38)
   40-49 313 2,912 35 (47) 120 1.00 1.00 1.00
   50-59 434 3,881 58 (90) 149 1.25 (0.82-1.90) 1.38 (0.90-2.10) 1.44 (0.94-2.20)
   60-69 579 5,119 57 (143) 111 0.93 (0.61-1.41) 0.89 (0.58-1.36) 0.90 (0.58-1.38)
   70-79 373 2,860 60 (187) 210 1.75 (1.15-2.66) 1.55 (1.01-2.37) 1.51 (0.97-2.35)
   ≥80 123 714 13 (98) 182 1.54 (0.81-2.91) 1.25 (0.66-2.38) 1.44 (0.74-2.78)
   All 1,906 16,228 238 (583) 147    
Positive 5- year follow-up <40 75 301 28 (32) 930 1.19 (0.78-1.82) 1.33 (0.87-2.04) 1.07 (0.69-1.66)
   40-49 274 1,141 89 (95) 780 1.00 1.00 1.00
   50-59 376 1,498 130 (139) 868 1.12 (0.85-1.46) 1.23 (0.94-1.61) 1.29 (0.98-1.70)
   60-69 383 1,526 128 (158) 839 1.08 (0.82-1.41) 1.20 (0.92-1.58) 1.30 (0.98-1.72)
   70-79 283 1,059 86 (134) 812 1.05 (0.78-1.41) 1.11 (0.82-1.50) 1.21 (0.88-1.66)
   ≥80 124 383 47 (81) 1,227 1.60 (1.13-2.29) 1.38 (0.96-1.98) 1.68 (1.14-2.25)
   All 1,515 5,908 508 (639) 860    
  10-year follow-up <40 75 472 42 (46) 890 1.39 (0.98-2.00) 1.55 (1.09-2.21) 1.34 (0.94-1.93)
   40-49 274 1,954 121 (128) 619 1.00 1.00 1.00
   50-59 376 2,530 177 (198) 700 1.13 (0.90-1.42) 1.25 (0.99-1.57) 1.26 (1.00-1.60)
   60-69 383 2,461 174 (228) 707 1.12 (0.89-1.42) 1.25 (0.99-1.58) 1.27 (1.00-1.63)
   70-79 283 1,580 112 (217) 709 1.10 (0.85-1.42) 1.14 (0.88-1.48) 1.22 (0.93-1.60)
   ≥80 124 523 53 (106) 1,013 1.54 (1.11-2.13) 1.30 (0.93-1.81) 1.61 (1.13-2.28)
   All 1,515 9,520 679 (923) 713    
  1. CI = Confidence Intervals.
  2. a Breast cancer-specific mortality per 10,000 person-years.
  3. bAdjusted for tumor size and distant metastasis.
  4. cAdjusted for diagnostic period, BMI, parity, tumor size, histological type, tumor location, and distant metastasis.