Figure 3

Left axillary recurrence from breast cancer: (a) Preoperative patient diagnostic PET/CT scan demonstrating an ¹⁸F-FDG-avid lesion in the left axilla (red circle). (b) Postoperative patient diagnostic PET/CT demonstrating complete removal of the ¹⁸F-FDG-avid lesion (red circle). (c) Digital photo of the WSRS (i.e., left axillary lymph node dissection specimen), with the white circle corresponding to a suspicious palpable lymph node that is to be further processed. (d) Clinical PET/CT specimen image and (e) micro PET/CT specimen image of the WSRS, with the red circle demonstrating the ¹⁸F-FDG-avid lesion that is to be further processed. (f) Digital photo depicting the first phase of the pathologic processing that produced the RDT, which consists of a single 0.5 cm slice through a piece of tissue containing the suspicious palpable lymph node. (g) Clinical PET/CT specimen image and (h) micro PET/CT specimen image of the RDT, demonstrating the ¹⁸F-FDG-avid lesion that corresponds to the piece of tissue containing the suspicious palpable lymph node. (i) Digital photo after sectioning of the RDT into four pieces of tissue, designated as SRDT, with visible tumor seen within the piece of tissue shown in the red square. (j) Clinical PET/CT specimen image and (k) micro PET/CT image of the SRDT, demonstrating ¹⁸F-FDG avidity within the piece of tissue shown in the red square that corresponds to the visible tumor within the previously processed portion of the suspicious palpable lymph node. (l) H&E stained, whole-mount slide (0.4× magnification) of the specific SRDT piece that is highlighted in the red square in (i), (j), and (k), demonstrating histologic confirmation breast cancer within the corresponding previously processed portion of the suspicious palpable lymph node. Each division of the hatched line in (c), (f), and (i) represents 1 cm.