Table 1 Characteristics of the included studies
From: Surgical treatment of primitive gastro-intestinal lymphomas: a systematic review
Author/Year | Types of study | N° of total evaluated patients | Inclusion criteria | Surgical treatment +/- medical theraphy | Medical theraphy alone | Mean follow-up | Results | |
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Â | Â | Overall survival | Event-free survival |
Avilés et al. [8] 2005 | RCT Open-label | 241 | Patients with low-grade gastric MALT lymphoma age < 70 yr old, no gender difference, ECOG status ≤2, immunodeficiency virus test negative, tumor mass > 5, previously untreated, stage I or IIE (according to the Lugano Conference criteria) | 80 patients received surgery alone (total gastrectomy) | 78 patients received only radiotherapy 83 patients received only chemotherapy | 7, 5 years (range 4.8-11.6 yr) | 10 years 80% S group 75% R group 85% C group | 10 years 52% S group 52% R group 87% C group |
Gobbi et al. [10] 2000 | PNR | 154 | Patients who fulfilled Lewin's criteria for diagnosing PGL (stomach and intestinal). Low-grade MALT lymphomas were excluded from this study | 106 patients received chemotherapy plus surgery | 48 patients received chemotherapy Radiotherapy was optionally given only when residual tumor masses seemed to persist at restaging after primary therapy or when bulky masses were present at onset. | NI | NI | NI |
Popescu et al. [9] 1990 | PNR | 37 | Patients with a histological diagnosis of intermediate or high-grade NHL according to the Working Formulation (WF) involving the stomach were included. Patients who received radiotherapy but no chemotherapy treatment were not included. Patients in whom lymphoma diagnosis predated demonstration of gastric involvement or where the bulk of the disease and its manifestations was extra-abdominal, nodal, hepatic or splenic were considered to have secondary involvement of the stomach were excluded. | 13 Surgery and chemotherapy 5 total gastrectomy 8 partial gastrectomy | 24 patients received chemotherapy alone | 53 months | 5 years 60% in S+C group 67% in medical therapy group | 5 years 85 > % % in S+C group 62% in medical therapy group |
Binn et al. [11] 2003 | PNR Multicentric | 84 | Patients with diffuse large B-cell primary gastric lymphoma with stage IE and IIE according to the Ann Arbor staging system. Mediterranean lymphoma, human immunodeficiency virus-related lymphoma and post-transplantation lymphoma were not included. | 40 patients received surgery plus chemotherapy 21 total gastrectomy 19 partial gastrectomy | 44 patients received chemotherapy alone 7 patients received additional radiotherapy | 59 months (range 3-128) | 5 years 90, 5% in S+C group 91, 1% in medical therapy group | 5 years 85, 5% in S+C group 91, 6% in medical terapy group |
Koch et al. [6] 2001 | PNR Multicentric | 185 | Patients with all histological tips of gastric low and high grade lymphoma but only in stage I E and II E 1- 2. Patients who were older than 75 years and/or presented with second malignancies, had missing confirmation of histologic subtype by central review, or had comorbidity prohibiting therapy were excluded from study | 79 patients received complete or partial resection in combination with radio- and/or chemotherapy | 106 patients received only radio- and/or chemotherapy | 52 months (range 0-92 months) | 5 years 84, 2% in medical therapy group 82% Combined surgical treatment | 5 years 78.7% in medical therapy group 78, 9% Combined surgical treatment |