Changes in the ER, PgR, HER2, p53 and Ki-67 biological markers between primary and recurrent breast cancer: discordance rates and prognosis

Table 3 Changes in biological marker status (category) between primary breast tumors and matched recurrent lesions

Marker	Decrease	Increase	% Change	p value	p value
	primary → recurrence			* PgR	** Ki-67
ER	+ → - : 8	- → + : 2	10/97 (10.3)	0.009	0.03
PgR	+ → - : 19	- → + : 6	25/97 (25.8)*		0.74
p53	+ → - : 5	- → + : 7	12/97 (12.4)	0.028	0.09
HER2	+ → - : 3	- → + : 11	14/97 (14.4)	0.073	0.20
Ki-67 Index	+ → - : 5	- → + : 17	22/97 (22.6)**	0.74

ISSN: 1477-7819