Table 1 Case reports of appendiceal epithelial (mucinous) tumors during pregnancy.
From: Management of appendiceal pseudomyxoma peritonei diagnosed during pregnancy
Reference and year | Diagnosis | Gestational age at presentation | Clinical presentation | Initial treatment of appendiceal tumor | Definitive treatment of appendiceal tumor | Management and outcome of pregnancy | Patient outcome and follow-up |
|---|---|---|---|---|---|---|---|
Haase (current case) | Well-differentiated mucinous adenocarcinoma with pseudomyxoma peritonei syndrome | 17 weeks | Incidental finding on routine prenatal ultrasound | Laparotomy, right salpingo-oophorectomy, appendectomy, omental biopsy | Complete cytoreductive surgery with HIPEC and EPIC after delivery, and adjuvant chemotherapy | Early induction and vaginal delivery of healthy baby at 35 weeks | 5 years, no recurrence |
Sebire 2000 [7] | Moderately-differentiated appendiceal adenocarcinoma with peritoneal carcinomatosis and liver metastases | 29 weeks | Lower abdominal pain and vomiting | Diagnostic workup of metastatic disease (liver biopsy) | Palliative debulking (omentectomy, appendectomy, left oophorectomy) at time of Cesarean section. Adjuvant 5-FU, epirubicin and carboplatin | Cesarean section at 30 weeks, healthy baby | 6 months post treatment clinically well but residual tumor in right iliac fossa and liver |
Gallo 2001 [11] | Well-differentiated mucinous cystadenocarcinoma | 38 weeks | Incidental finding at Cesarean section | Appendectomy at time of Cesarean section | Right hemicolectomy after radiographic metastatic workup | Cesarean section at 38 weeks | 5 years, no recurrence |
Donnenfeld 1986 [12] | Perforated mucinous appendiceal adenocarcinoma | 31 weeks | Acute abdomen, | Appendectomy | Right hemicolectomy 9 days postpartum | Early induction and vaginal delivery of healthy baby at 33 weeks | 30 day follow up no complications |
Morgan 2004 [13] | Well-differentiated mucinous adenocarcinoma, negative peritoneal washings | 26 weeks | Acute abdomen | Right hemicolectomy | No further treatment | Vaginal delivery of healthy baby at term | 36 months, no recurrence |
Zeteroglu 2003 [14] | Mucinous appendiceal cystadenocarcinoma | 21 weeks | Acute abdomen | Appendectomy | Right hemicolectomy, omentectomy | Terminated at 21 weeks | 1 year, no recurrence |
Casey 2003 [15] | Perforated mucinous cystadenoma | 21 weeks | Acute abdomen | Appendectomy | No further treatment | miscarriage | Discharged well 4 days after surgery |
Kalu 2005 [16] | Mucinous adenoma with mucocele | 5 weeks | Incidental ultrasound finding at time of vaginal bleeding | Observation with serial imaging (follow-up ultrasound 3 months) | Appendectomy 3 months later when mass doubled in size | Spontaneous abortion at 6 weeks | Discharged well 4 days after surgery |