Table 1 Primary cutaneous neuroendocrine tumours
From: Neuroendocrine carcinoma arising in soft tissue: three case reports and literature review
Reference | Age M/F | Clinical | Ultrastructure | Treatment | Course |
|---|---|---|---|---|---|
Van Dijk C et al, 1975 [7] | 72 yr Female | Cystic lesion on forehead with flushing | Argophyllic granules | Excision | Flushing resolved. No recurrence × 1 yr |
Brody HJ et al, 1979 [8] | 75 yr Female | Hyperpigmented nodule with periumbilical induration. Elevated 5HIAA. Associated hyperparathyroidism | Strongly positive argentaffin reaction | Excision | Not given in report |
Collina et al, 1988 [26] | 80 yr Male | Nodule behind right ear × 12 m | Argophyllic granules. Chromgranin positive Negative argentaffin reaction | Wide excision | No recurrence 21 months later |
Bart RS et al, 1990 [9] | 40 yr Male | Red-tan soft nodule on abdomen × 4 years | Argophyllic large and varied granules. NSE, keratin +ve | Wide excision | Alive and well 2 years later |
Smith PA et al, 1995 [10] | 62 yr Female | Firm blue-ish nodule on chest | Argophyllic granules. Postive argentaffin reaction | Wide excision | Alive at 4 years. Well apart from claudication |
Courville P et al, 2000 [11] | 60 yr Male | Erythematous nodule on chest | Argophyllic granules. Positive argentaffin reaction. Chromogranin A, NSE | Excision | Alive without recurrence 4 years after excision |
MacKenzie DN et al, 2003 [12] | 70 yr Female | Hard node on scalp with metastasis to occipital lymph node | Synaptophysin, NSE, keratin, CEA +ve | Excision of lesion and occipital lymph node | 4 years later further lymph node metastasis. Metastatic node recurrence 2 years later |