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Table 2 Maximum severity of adverse events in each 6 patients.

From: Preliminary results of phase I trial of oral uracil/tegafur (UFT), leucovorin plus irinotecan and radiation therapy for patients with locally recurrent rectal cancer

NCI-CTC grade

Case#

  

#1

#2

#3

#4

#5

#6

Hematological

       
 

Leukopenia

0

0

0

3

0

2

 

Neutropenia

0

0

1

2

0

2

 

Anemia

1

1

1

2

1

0

 

Thrombocytopenia

0

0

0

0

0

0

Gastrointestinal

       
 

Appetite loss

1

1

1

2

1

0

 

Diarrhea

0

1

3

3

3

3

 

Nausea/vomiting

1

1

0

2

1

0

 

Abdominal pain

1

1

1

3

1

2

  1. Grade 3 diarrhea occurred at day 18 (#3), 25 (#4), 21 (#5), and 19 (#6)
  2. Case #4 had bowel fistula which required surgical intervention.