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Table 1 Four different studies showing that between 40% to 70% of previously untreated NPC specimens have loss of p16 expression.

From: Cyclin D1 and p16 expression in recurrent nasopharyngeal carcinoma

Investigators

Number of NPC specimens examined

Percent of NPC with loss of p16 staining

Hwang et al [13]

65

65%

Makitie et al [16]

84

70%

Huang et al [15]

74

42%

Baba et al [14]

20

40%

Lin et al [this study]

27

96%

  1. This is in contrast to the 96% of recurrent NPC found in this study to have loss of p16 expression.