Malignant peripheral nerve sheath tumors (MPNST) – Clinicopathological study and treatment outcome of twenty-four cases

Table 2 Prognostic factors affecting disease free survival and overall survival in univariate analysis.

Variables	Chi Square	95% C.I.	P Value
DFS
1. Sex	3.84	0.92 – 12.93	0.05*
2. Tumor depth	4.23	5.3 – 9.4	<0.03*
3. VRHD	0.28	0.28 – 3.9	0.59
4. Tumour Necrosis	0.56	0.2 – 10.4	<0.76
5. Tumor mitosis	0.027	0.22–3.53	>0.86
6. Cellular differentiation	11.95	2.01 – 111.75	<0.002*
7. Tumor grade	1.69	0.14 – 1.51	>0.19
8. Heterogeneous differentiation	1.73	0.14 – 1.48	0.18
9. RT	2.49	0.76 – 8.42	0.11
OS
1. Sex	4.02	0.94 – 13.27	0.04*
2. Tumor depth	1.86	0.4 – 1.18	0.17
3. VRHD	0.15	0.18 – 4.08	>0.37
4. Tumor Necrosis	0.6	0.2–14.2	>0.74
5. Tumor Mitosis	0.012	0.2–4.8	>0.98
6. Cellular differentiation	15.50	2.44 – 334.28	<0.0004*
7. Tumor grade	3.84	0.94 – 4.68	0.05*
8. Heterogeneous differentiation	0.89	0.15 – 1.95	0.34
9. RT	2.66	0.10 – 1.28	>0.10
10. Recurrence	9.49	0.3 – 2.61	<0.002*

C.I. = Confidence Interval, DFS = Disease free survival, OS = Overall survival, VRHD = Von Reckling hausen's disease, RT = Radiotherapy, *: Statistically Significant.

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