Table 1 Clinical distinctions between primary hyperthyroidism and parathyroid carcinoma. Adapted from [38].
From: Normocalcemic parathyroid carcinoma: an unusual clinical presentation
Parathyroid carcinoma | Primary hyperparathyroidism | |
|---|---|---|
Palpable neck mass | 50% | <10% |
Hypercalcemia (normal = 8.5–9.9 mg/dL) | > 14 mg/dL | 11–12 mg/dL |
↑ PTH (normal = 10–65 pg/mL) | 3–10× normal | 2× normal |
Renal impairment (nephrilithiasis, nephrocalcinosis, impaired GFR) | 32–84% | <20% |
Skeletal abnormalities (osteitis fibrosa cystica, diffuse spinal osteopenia, subperiosteal bone resorption, salt-and-pepper skull) | 44–91% | <10% |