I read always with great pleasure data of researchers who suggest the genetic factor of cancer. However, I am sorry to find out that "Oncological Terrain", I described formerly, is completely overlooked by authors all around the World ( See my site http://www.semeioticabiofisica.it, Oncological Terrain, ans Bibliography). As a matter of fact, in my 48-year long, well established, and clinical experience, in the war against cancers, we have particularly to discover somethingh that allows “all” doctors to recognize promptly, at the bed side, i.e. "clinically", even in apparently healthy individuals, not only such as abnormality, like hyperinsulinemia-insulinresistance and/or melatonine deficiency and/or excessive prolactin production and/ or endogenous oppioids deficiency, a.s.o., which either bring about or aggravate chromosomal aberrations as those observed in cancer cells. Therefore, we can hopefully reache our goal if all doctors, in apparently healthy persons, are able either to ascertain, or at least suspect, at the bed-side chromosomal aberrations, before cancer on-set, and/or neuro-psycho-endocrine-immunological genetic abnormality, which, consequently, can not allow the body to eliminate the cells involved by such as chromosomal aberrattion. I naimed such as genetic abnormality of control biological system Oncological Terrain (1) (See the above-cited site).
As a working hypothesis, I thought that all chromosomal alterations of whatever location, nature and degree, causing oncogenesis, are necessarily accompanied by similar microvascular modification, structural and functional in nature, of the local microcirculatory bed. As a matter of fact, both genetical and environmental factors induce contemporaneously parenchymal and microvascular cells abnormalities, according to the well-known concept of Tiscedorf’s “Angiobiotopie”. For instance, a family of molecules called cyclins was descovered. It is through changes in the production of cyclins during the cell cycle that the activity of the genes controlling it are themselves regulated. All these events (control, regulation a.s.o.), however, can happen only by means of changes in local microcirculation, which now fortunately, thanks to Biophysical Semeiotics, can be evaluate clinically, in a precise manner (2-5).
My theory of “oncological terrain”, supported by a 47-year long "clinical" experience, allows me to state that the decline in cancer rates all over the world could be more intense than now, only if scientists would think over and discuss, fortunately, the possibility that the "Oncological Terrain" exists. As a matter of fact, e.g., not all smokers are involved by pulmonary cancer, as well as not all people with chronic hepatitis will die of hepatocarcinoma. On the other side, in some families malignancies occur more frequently than in others. Actually, as I described early in the above-mentioned papers, there are other causes that account for the reason of the existence of mother-dependent oncological “real” risk, i.e. oncological terrain: it is non-sense, or at least useless, to ask a patient if father is or was involved by cancer.
At this point, the first question is the following: "What does characterize oncological terrain from the "clinical" point of view"?. In fact, in order to achieve efficacious cancer prevention on very large scale it is unavoidable that the modifications occurring in the biological controll system could be easily, promptly, and “quantitatively” ascertained and properly evaluated with the aid of a “clinical” method, i.e. by the use of a sthetoscope, and certainly without application of sophysticated semeiotics, that does not surely be applyed in all individuals, and, moreover, only a few doctors can utilize them.
If it is possible to answer such as first question, a second one immediately follows: "The oncological terrain which is certanly genetically provoked, is also in some way reversible?" It is urgent and necessary to know if inherited oncological terrain can be reversed, i.e. if it can totally or greatly disappear, with the aid of drugs or diet, ethymologically speaking, which exert a favourable influence on the characteristic modifications of the psicho-neuro-endocrine- immunological system, that really represent the “oncological terrain”. My answers to these questions are readable in my above-cited site (5).
The war against cancer will be fortunately won if all doctor are going to recognize, with the aid of a stethoscope, individual apparently healthy but positive for “oncological terrain”, particularly intense, who have to undergo immediately to proper diet, ethymologically speaking, and drugs, only in some cases.
Unfortunately, change in Medicine is an up-hill task! Moreover, in the discussion between theories the power of the antagonists is more important than that of the ideas. But, fortunately, “good” ideas go on and on, and on...
Stagnaro Sergio MD.
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
2) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica del torace, della circolazione ematica e dell’anticorpopoiesi acuta e cronica. Acta Med. Medit. 13, 25 1997
3) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: la manovra di Ferrero-Marigo nella diagnosi clinica della iperinsulinemia-insulino resistenza. Acta Med. Medit. 13, 125 1997
4) Stagnaro-Neri M., Stagnaro S., Cancro della mammella: prevenzione primaria e diagnosi precoce con la percussione ascoltata. Gazz. Med. It. – Arch. Sc. Med. 152, 447, 1993.
5) Stagnaro S., Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. letter [MEDLINE].
6) Stagnaro S. Bed-Side Prostate Cancer Detecting, even in early stages (“Real Risk” of Cancer): BMC Family Practice, 2005, 6:24 doi:10.1186/1471-2296-6-24
Genes, Oncological Terrain, and Breast Cancer
22 July 2005
Sirs,
I read always with great pleasure data of researchers who suggest the genetic factor of cancer. However, I am sorry to find out that "Oncological Terrain", I described formerly, is completely overlooked by authors all around the World ( See my site http://www.semeioticabiofisica.it, Oncological Terrain, ans Bibliography). As a matter of fact, in my 48-year long, well established, and clinical experience, in the war against cancers, we have particularly to discover somethingh that allows “all” doctors to recognize promptly, at the bed side, i.e. "clinically", even in apparently healthy individuals, not only such as abnormality, like hyperinsulinemia-insulinresistance and/or melatonine deficiency and/or excessive prolactin production and/ or endogenous oppioids deficiency, a.s.o., which either bring about or aggravate chromosomal aberrations as those observed in cancer cells. Therefore, we can hopefully reache our goal if all doctors, in apparently healthy persons, are able either to ascertain, or at least suspect, at the bed-side chromosomal aberrations, before cancer on-set, and/or neuro-psycho-endocrine-immunological genetic abnormality, which, consequently, can not allow the body to eliminate the cells involved by such as chromosomal aberrattion. I naimed such as genetic abnormality of control biological system Oncological Terrain (1) (See the above-cited site).
As a working hypothesis, I thought that all chromosomal alterations of whatever location, nature and degree, causing oncogenesis, are necessarily accompanied by similar microvascular modification, structural and functional in nature, of the local microcirculatory bed. As a matter of fact, both genetical and environmental factors induce contemporaneously parenchymal and microvascular cells abnormalities, according to the well-known concept of Tiscedorf’s “Angiobiotopie”. For instance, a family of molecules called cyclins was descovered. It is through changes in the production of cyclins during the cell cycle that the activity of the genes controlling it are themselves regulated. All these events (control, regulation a.s.o.), however, can happen only by means of changes in local microcirculation, which now fortunately, thanks to Biophysical Semeiotics, can be evaluate clinically, in a precise manner (2-5).
My theory of “oncological terrain”, supported by a 47-year long "clinical" experience, allows me to state that the decline in cancer rates all over the world could be more intense than now, only if scientists would think over and discuss, fortunately, the possibility that the "Oncological Terrain" exists. As a matter of fact, e.g., not all smokers are involved by pulmonary cancer, as well as not all people with chronic hepatitis will die of hepatocarcinoma. On the other side, in some families malignancies occur more frequently than in others. Actually, as I described early in the above-mentioned papers, there are other causes that account for the reason of the existence of mother-dependent oncological “real” risk, i.e. oncological terrain: it is non-sense, or at least useless, to ask a patient if father is or was involved by cancer.
At this point, the first question is the following: "What does characterize oncological terrain from the "clinical" point of view"?. In fact, in order to achieve efficacious cancer prevention on very large scale it is unavoidable that the modifications occurring in the biological controll system could be easily, promptly, and “quantitatively” ascertained and properly evaluated with the aid of a “clinical” method, i.e. by the use of a sthetoscope, and certainly without application of sophysticated semeiotics, that does not surely be applyed in all individuals, and, moreover, only a few doctors can utilize them.
If it is possible to answer such as first question, a second one immediately follows: "The oncological terrain which is certanly genetically provoked, is also in some way reversible?" It is urgent and necessary to know if inherited oncological terrain can be reversed, i.e. if it can totally or greatly disappear, with the aid of drugs or diet, ethymologically speaking, which exert a favourable influence on the characteristic modifications of the psicho-neuro-endocrine- immunological system, that really represent the “oncological terrain”. My answers to these questions are readable in my above-cited site (5).
The war against cancer will be fortunately won if all doctor are going to recognize, with the aid of a stethoscope, individual apparently healthy but positive for “oncological terrain”, particularly intense, who have to undergo immediately to proper diet, ethymologically speaking, and drugs, only in some cases.
Unfortunately, change in Medicine is an up-hill task! Moreover, in the discussion between theories the power of the antagonists is more important than that of the ideas. But, fortunately, “good” ideas go on and on, and on...
Stagnaro Sergio MD.
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
2) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica del torace, della circolazione ematica e dell’anticorpopoiesi acuta e cronica. Acta Med. Medit. 13, 25 1997
3) Stagnaro-Neri M., Stagnaro S., Semeiotica Biofisica: la manovra di Ferrero-Marigo nella diagnosi clinica della iperinsulinemia-insulino resistenza. Acta Med. Medit. 13, 125 1997
4) Stagnaro-Neri M., Stagnaro S., Cancro della mammella: prevenzione primaria e diagnosi precoce con la percussione ascoltata. Gazz. Med. It. – Arch. Sc. Med. 152, 447, 1993.
5) Stagnaro S., Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. letter [MEDLINE].
6) Stagnaro S. Bed-Side Prostate Cancer Detecting, even in early stages (“Real Risk” of Cancer): BMC Family Practice, 2005, 6:24 doi:10.1186/1471-2296-6-24
http://www.biomedcentral.com/1471-2296/6/24/comments#202466 .
7) Stagnaro S. There is another clinical, and overlooked tool, reliable in breast cancer prognosis evaluation (06 July 2005). BMC Cancer.
http://www.biomedcentral.com/1471-2407/5/70/comments#204473
Competing interests
None declared