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Table 10 Comparison of endoscopic surveillance methods for Barrett's oesophagus

From: Barrett's oesophagus and adenocarcinoma

Method Description Sensitivity for HGD Resolution FOV Depth (□m) Cost Time
4 quadrant biopsy Random biopsies every 2 cm ++ + ++++ 1000 +++ +++
Chromoendoscopy Dye enhanced mucosal view +/- ++ ++++ none + ++
High magnification endoscopy Magnified view mucosal surface +/- acetic acid +/- +++ + none ++ +++
Light induced fluorescence Endogenous fluorescence +/- + ++++ 200 +++ ++
Photodynamic diagnosis Exogenous fluorescence +/- + ++++ 200 +++ +++
Elastic scattering endoscopy Backscattered visible light from cellular microstructures + +++ ++ 1000 + +
Optical coherence tomography Backscattered infrared from cellular microstructures +/- +++ ++ 500 ++++ ++
High frequency ultrasound Backscattered acoustic waves from cellular microstructures +/- ++ ++ 1000 +++ ++++
Confocal microscopy Miniature microscope with subcellular resolution ? ++++ + 500 ++ ++