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Table 10 Comparison of endoscopic surveillance methods for Barrett's oesophagus

From: Barrett's oesophagus and adenocarcinoma

Method

Description

Sensitivity for HGD

Resolution

FOV

Depth (â–¡m)

Cost

Time

4 quadrant biopsy

Random biopsies every 2 cm

++

+

++++

1000

+++

+++

Chromoendoscopy

Dye enhanced mucosal view

+/-

++

++++

none

+

++

High magnification endoscopy

Magnified view mucosal surface +/- acetic acid

+/-

+++

+

none

++

+++

Light induced fluorescence

Endogenous fluorescence

+/-

+

++++

200

+++

++

Photodynamic diagnosis

Exogenous fluorescence

+/-

+

++++

200

+++

+++

Elastic scattering endoscopy

Backscattered visible light from cellular microstructures

+

+++

++

1000

+

+

Optical coherence tomography

Backscattered infrared from cellular microstructures

+/-

+++

++

500

++++

++

High frequency ultrasound

Backscattered acoustic waves from cellular microstructures

+/-

++

++

1000

+++

++++

Confocal microscopy

Miniature microscope with subcellular resolution

?

++++

+

500

++

++