DJ-1 is activated in medulloblastoma and is associated with cell proliferation and differentiation

Table 1 Correlation between proteins expression and clinicopathological characteristics of patients with MB

Clinicopathological characteristics	DJ-1 expression^a		p-Akt expression^a		Proliferative activity (Ki-67 value)^b
	Low (n = 34)	High (n = 32)	Low (n = 29)	High (n = 37)
Age, year
≤3 (n = 19)	13	6	7	12	25.28 ± 7.59
>3 (n = 47)	21	26	22	25	26.77 ± 8.74
P value	0.030		0.275		0.519
Sex
Male (n = 43)	23	20	18	25	25.80 ± 7.31
Female (n = 23)	11	12	11	12	27.36 ± 10.23
P value	0.619		0.527		0.475
WHO histological subtype ^c
Classic (n = 50)	23	27	22	28	25.17 ± 7.75
Desmoplastic (n = 14)	11	3	7	7	30.03 ± 9.89
P value	0.003		0.536		0.055
Tumor location
Fourth ventricle (n = 29)	16	13	10	19	26.65 ± 8.51
Outside fourth ventricle (n = 37)	18	19	19	18	26.11 ± 8.42
P value	0.556		0.065		0.795
Residual tumor size
≤1.5 cm² (n = 54)	29	25	24	30	25.75 ± 8.14
>1.5 cm² (n = 12)	5	7	5	7	29.04 ± 9.38
P value	0.221		0.829		0.222
Metastatic status
M0 (n = 12)	5	7	3	9	28.20 ± 7.39
M1 (n = 54)	29	25	26	28	25.93 ± 8.61
P value	0.221		0.007		0.401
Tumor risk
Standard (n = 6)	2	4	1	5	30.50 ± 9.58
High (n = 60)	32	28	28	32	25.93 ± 8.25
P value	0.031		0.010		0.201
Differentiation level
Undifferentiated (n = 39)	14	25	13	26	27.28 ± 8.82
Differentiated (n = 27)	20	7	16	11	25.00 ± 7.71
P value	0.001		0.007		0.281
DJ-1 expression
Low (n = 34)			20	14	23.33 ± 6.22
High (n = 32)			9	23	29.54 ± 9.28
P value			0.001		0.002
p-Akt expression
Low (n = 29)	20	9			25.13 ± 6.92
High (n = 37)	14	23			27.29 ± 9.38
P value	0.001				0.303

^aχ² test.
^bOne-way ANOVA.
^cWe did not carry out statistical analysis for the large cell/anaplastic variant and medullomyoblastoma because there were insufficient numbers of cases.

ISSN: 1477-7819