Expression of DNA-repair proteins and their significance in pancreatic cancer and non-cancerous pancreatic tissues of Sprague–Dawley rats

Table 3 Expression of MGMT, ERCC₁, hMSH₂, and hMLH₁in ductal adenocarcinoma and non-cancerous pancreatic tissues (%)

Group	n	MGMT	ERCC₁	hMSH₂	hMLH₁
Pancreatic ductal adenocarcinoma
A + B	28	15 (53.6)	13 (46.2)	14 (50.0)	12 (42.9)
A	17	9 (52.9)	8 (47.1)	9 (52.9)	8 (47.1)
B	11	6 (54.6)	5 (45.5)	5 (45.5)	4 (36.4)
Non-cancerous pancreatic tissues
A + B	43	35 (81.4)	33 (76.7)	32 (74.4)	30 (70.0)
A	19	14 (73.7)	14 (73.7)	12 (63.2)	11 (57.9)
B	24	21 (87.5)	19 (79.2)	19 (79.2)	19 (79.2)

Pancreatic ductal adenocarcinoma compared with non-cancerous pancreatic tissues in group A + B: χ²_MGMT = 6.30, P <0.05; χ²_ERCC1 = 6.83, P <0.01; χ²_hMSH2 = 4.43, P <0.05; χ²_hMLH1 = 5.08, P <0.05.
Pancreatic ductal adenocarcinoma compared with non-cancerous pancreatic tissues in group A: P_MGMT = 0.157, P_ERCC1 = 0.088, P_hMSH2 = 0.103, P_hMLH1 = 0.452.
Pancreatic ductal adenocarcinoma compared with non-cancerous pancreatic tissues in group B: P_MGMT = 0.042, P_ERCC1 = 0.050, P_hMSH2 = 0.050, P_hMLH1 = 0.018.

ISSN: 1477-7819