High expression of thymosin beta 10 predicts poor prognosis for hepatocellular carcinoma after hepatectomy

Table 2 Univariate and multivariate analyses of overall and disease-free survival for 196 hepatocellular carcinoma (HCC) patients

Variables	Univariate analysis	Multivariate analysis
Variables	P value	HR (95% CI)	P value
Overall survival
Age (≤50 y versus >50 y)	0.429
Gender (male versus female)	0.713
HBV infection (absent versus present)	0.10
AFP level (≤25 ng/ml versus >25 ng/ml)	0.234
Liver cirrhosis (absent versus present)	0.026
Tumor size (≤5 cm versus >5 cm)	0.024
Tumor number (single versus multiple)	0.042
TNM stage (I to II versus III)	<0.001	1.649 (1.091 to 2.492)	0.018
Tumor differentiation (I to II versus III to IV)	0.018
Vascular invasion (present/absent)	<0.001	2.051 (1.288 to 3.264)	0.002
Tbeta10 (low versus high)	<0.001	4.135 (2.603 to 6.569)	0.001
Disease-free survival
Age (≤55 y versus >55 y)	0.523
Gender (male versus female)	0.515
HBV infection (absent versus present)	0.009
AFP level (≤25 ng/ml versus >25 ng/ml)	0.170
Liver cirrhosis (absent versus present)	0.361
Tumor size (≤5 cm versus >5 cm)	0.006	1.483 (1.047 to 2.100)	0.027
Tumor number (single versus multiple)	0.018
TNM stage (I to II versus III)	<0.001	1.537 (1.060 to 2.228)	0.023
Tumor differentiation (I to II versus III to IV)	0.003
Vascular invasion (present/absent)	<0.001	2.082 (1.378 to 3.145)	0.001
Tbeta10 (low versus high)	<0.001	2.021 (1.442 to 2.832)	0.001

AFP, alpha fetoprotein; HBV, hepatitis B virus; HR, hazard ratio; Tbeta10, thymosin beta 10.

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