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Table 2 HRs and 95% CIs of various comparisons between molecular subtypes of breast cancer stratified by recurrence types

From: The efficacy of molecular subtyping in predicting postoperative recurrence in breast-conserving therapy: a 15-study meta-analysis

First author and publishing year

Types of recurrence

LBvs. LA

Her-2vs. LA

TNvs. LA

TNvs. non-TN

ER -vs.+

PR -vs.+

Her-2 +vs.-

p53 +vs.-

  

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Hattangadi[30]

TR

NM

NM

NM

4.80 (1.40, 15.80)M

NM

NM

NM

NM

Zauls[31]

LF

NM

NM

NM

NM

0.75 (0.15, 3.85)U

0.55 (0.12, 2.44)U

0.64 (0.07, 5.88)U

NM

Han[32]

LR

1.90 (0.90, 4.00)U

1.90 (0.90, 3.80)U

0.60 (0.10, 2.40)U,DE

NM

0.87 (0.48, 1.58)U

1.09 (0.61, 1.98)U,DE

1.98 (1.11, 3.53)M,DE

NM

Millar[33]

LR

2.48 (0.98, 6.29)M

1.93 (0.38, 9.75)M

3.94 (1.28, 12.11)M

NM

NM

NM

NM

1.20 (0.57, 2.55)U,DE

Millar[33]

DM

2.87 (1.33, 6.22)M

1.83 (0.39, 8.64)M

3.27 (1.14, 9.40)M

NM

NM

NM

NM

2.57 (1.30, 5.06)U

Millar[33]

LR + DM

2.71 (1.49, 4.90)M,DE

1.88 (0.61, 5.76)M,DE

3.89 (2.03, 7.44)M,DE

NM

NM

NM

NM

1.83 (1.10, 3.02)U,DE

Moran[34]

LR

NM

NM

NM

2.21 (0.63, 7.81)M

NM

NM

1.22 (0.30, 4.93)M

NM

Bantema[34]

LRR + DM

NM

NM

NM

3.03 (1.37, 6.67)M

NM

NM

NM

NM

Wong[35]

LR

NM

NM

NM

3.30 (1.20, 9.60)U

NM

NM

NM

NM

Wong[35]

DM

3.60 (1.10, 11.30)U

6.00 (1.60, 22.60)U

4.20 (1.10, 16.00)U

NM

NM

NM

NM

NM

Wong[35]

LR + DM

2.16 (0.85, 5.50)M

2.22 (1.08, 9.84)M

3.48 (1.22, 9.93)M

NM

NM

NM

NM

NM

Kim[36]

IBTR

1.55 (0.32, 7.51)M

0.55 (0.05, 6.34)M

1.17 (0.22, 6.26)M

NM

NM

NM

NM

NM

Arvold[38]

LR

2.10 (0.95, 4.80)M

5.20 (1.80, 15.00)M

3.90 (1.70, 9.00)M

NM

NM

NM

NM

NM

Truong[39]

LRR

NM

NM

NM

NM

1.29 (0.99, 1.69)M

NM

NM

NM

Sharon[40]

LR

NM

NM

NM

NM

NM

NM

1.93 (1.02, 3.65)M

NM

Roos[41]

LR

NM

NM

NM

NM

2.50 (0.42, 10.00)U,DE

1.11 (0.24, 5.00)U,DE

3.90 (0.80, 20.10)U

4.00 (0.90, 18.10)U

Yau[42]

IBTR

NM

NM

NM

NM

NM

NM

2.19 (0.76, 6.35)U

NM

Yau[42]

DF

NM

NM

NM

NM

NM

NM

2.17 (0.99, 4.75)U

NM

Yau[42]

IBTR + DF

NM

NM

NM

NM

NM

NM

1.57 (1.26, 1.97)U,DE

NM

Smith[43]

SIBC

NM

NM

NM

NM

NM

1.49 (1.00, 2.22)U

NM

NM

Silvestrini[44]

LR

NM

NM

NM

NM

1.12 (0.42, 2.97)U,DE

NM

NM

1.75 (1.44, 2.11)U,DE

  1. The source of HRs and 95% CIs is derived from univariate analysis (U), multivariate analysis (M) or data-extrapolated (DE).
  2. CI, confidence interval; DE, data-extrapolated; DF, distant failure; DM, distant metastasis; ER, estrogen receptor; Her-2, human epidermal growth factor receptor 2; HR, hazard ratio; IBTR, ipsilateral breast tumor recurrence; LA, Luminal A; LB, Luminal B; LF, local failure; LR, local recurrence or relapse; LRR, locoregional recurrence; NM, not mentioned; PR, progesterone receptor; SIBC, second ipsilateral breast cancer; TN, triple-negative; TR, true recurrence.