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Table 1 Demographics and clinicopathological data in patients with GIST according to Mcl-1 expression

From: Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors

 

Mcl-1 expression

   
 

Weak

Strong

Total No. of patients (%)

Univariate analysis

Multivariate analysis

<0.8

≥0.8

No. of patients (%)

No. of patients (%)

P value*

P value*

Number of patients

15 (48.4)

16 (51.6)

31 (100)

Age (years), mean ± SD

57.3 ± 14.4

63.2 ± 11.8

60.4 ± 13.3

0.225

0.505

Sex

     

  Male

7 (46.7)

8 (50)

15 (48.4)

0.853

0.465

  Female

8 (53.3)

8 (50)

16 (51.6)

  

Symptom and signs

     

  Yes

12 (80)

11 (68.7)

23 (74.2)

0.474

 

  No

3 (20)

5 (31.3)

8 (25.8)

  

Tumor location

     

  Stomach

5 (33.3)

12 (75)

17 (54.8)

0.020

0.051

  Intestine

10 (66.7)

4 (25)

14 (45.2)

  

Tumor size (cm), mean ± SD

8.0 ± 5.2

7.4 ± 4.5

7.7 ± 4.8

0.745

 

Mitosis (HPF), mean ± SD

20.3 ± 22.9

16.1 ± 31.7

18.1 ± 27.4

0.672

 

Recurrence

     

  Yes

5 (33.3)

4 (25)

9 (29)

0.609

 

  No

10 (66.7)

12 (75)

22 (71)

  

Osteopontin expression**

     

  Strong

5 (33.3)

13 (81.3)

18 (58.1)

0.007

0.015

  Weak

10 (66.7)

3 (18.7)

13 (41.9)

  
  1. SD indicates standard deviation; HPF: high-power fields.
  2. *Significant at the level of P <0.05.
  3. **Strong: 3+; Weak: <3 + .