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Table 1 Demographics and clinicopathological data in patients with GIST according to Mcl-1 expression

From: Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors

  Mcl-1 expression    
  Weak Strong Total No. of patients (%) Univariate analysis Multivariate analysis
<0.8 ≥0.8
No. of patients (%) No. of patients (%) P value* P value*
Number of patients 15 (48.4) 16 (51.6) 31 (100) – –
Age (years), mean ± SD 57.3 ± 14.4 63.2 ± 11.8 60.4 ± 13.3 0.225 0.505
Sex      
  Male 7 (46.7) 8 (50) 15 (48.4) 0.853 0.465
  Female 8 (53.3) 8 (50) 16 (51.6)   
Symptom and signs      
  Yes 12 (80) 11 (68.7) 23 (74.2) 0.474  
  No 3 (20) 5 (31.3) 8 (25.8)   
Tumor location      
  Stomach 5 (33.3) 12 (75) 17 (54.8) 0.020 0.051
  Intestine 10 (66.7) 4 (25) 14 (45.2)   
Tumor size (cm), mean ± SD 8.0 ± 5.2 7.4 ± 4.5 7.7 ± 4.8 0.745  
Mitosis (HPF), mean ± SD 20.3 ± 22.9 16.1 ± 31.7 18.1 ± 27.4 0.672  
Recurrence      
  Yes 5 (33.3) 4 (25) 9 (29) 0.609  
  No 10 (66.7) 12 (75) 22 (71)   
Osteopontin expression**      
  Strong 5 (33.3) 13 (81.3) 18 (58.1) 0.007 0.015
  Weak 10 (66.7) 3 (18.7) 13 (41.9)   
  1. SD indicates standard deviation; HPF: high-power fields.
  2. *Significant at the level of P <0.05.
  3. **Strong: 3+; Weak: <3 + .
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World Journal of Surgical Oncology

ISSN: 1477-7819

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