Figure 4
From: Response of an aggressive periosteal aneurysmal bone cyst (ABC) of the radius to denosumab therapy
Fluorescence in situ hybridization conducted on the pretreatment specimen with a custom-designed break apart probe set; the probe cocktail proximal to the USP6 locus is labeled in green and distal in red. The mononuclear nuclei exhibit one fused red/green signal corresponding to a normal 17p USP6 locus (black arrow) and a pair of split green and red signals (white arrows) indicating a rearrangement of the USP6 locus consistent with the diagnosis of aneurysmal bone cyst.