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Table 3 Perioperative fluid balance, blood loss, and substitution

From: Anaesthesia in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: retrospective analysis of a single centre three-year experience

  n Median (range)
Input   
Fluids   
Crystalloids; ml 57 5900 (2200–19100)
Crystalloids per hour; ml h−1   473 (187–1041)
Colloids; ml 56 2500 (500–14500)
Colloids per hour; ml h−1   189 (52–852)
  HES 130/0.4; ml 14 1000 (500–2500)
  Gelatine; ml 51 2500 (500–12000)
Blood products and coagulation factor concentrates   
PRBC; n 16 4 (1–10)
FFP; n 3 6 (4–8)
Thrombocytes; n 4 1 (1–2)
Fibrinogen; g 21 4 (2–22)
Prothrombin complex concentrate; IU 9 1000 (400–2000)
Factor XIII; IU 13 1500 (1250–4000)
Factor VIII-vWF; IU 1 1000
Recombinant factor VII; μg 1 1000
Total input; ml 57 8200 (4200–29400)
Total hourly input; ml h −1   697 (363–1603)
Output   
Blood loss; ml 57 800 (0–6000)
Urine; ml 57 1460 (330–3970)
  Urine per hour, CRS; ml h−1   94 (34–350)
  Urine per hour, HIPEC; ml h−1   220 (47–787)
  Urine per hour, reconstruction; ml h−1   183 (33–631)
Ascites; ml 11* 1500 (100–3000)
Total output; ml 57 2670 (530–10780)
Total hourly output; ml h −1   218 (58–729)
  1. 54 patients underwent 57 procedures. Data are expressed as median (range) and numbers (n).
  2. Fluids: Crystalloids = Ringerfundin™ (B.Braun Medical AG, Melsungen, Germany); Colloids = gelatine (Physiogel™ balanced, B. Braun Medical AG, Melsungen, Germany) and HES 130/0.4 (Tetraspan™, B. Braun Medical AG, Melsungen, Germany). PRBC and thrombocytes were applied in units of 300 ml, FFP in units of 280 ml.
  3. Coagulation factor concentrates: Fibrinogen (Hemocomplettan P™, CSL Behring AG, Bern, Switzerland), Prothrombin complex concentrate (PCC, Beriplex P/N™, CSL Behring AG, Bern, Switzerland), Factor XIII (Fibrogammin P™, CSL Behring AG, Bern, Switzerland), Factor VIII-vWF (Hemate P™, CSL Behring AG, Bern, Switzerland), recombinant activated Factor VIIa (Novoseven™, Novo Nordisk Pharma AG, Kusnacht, Switzerland).
  4. *data missing in 46 patients.
  5. HES, hydroxyethyl starch; IU, international units; PRBC, packed red blood cells; FFP, fresh frozen plasma; vWF, von Willebrand factor.