Intraoperative course of temperature and lactate. A. Change in temperature compared to baseline: the horizontal line set at 0 is representing baseline. If the 95% confidence interval presented for each time point does not overlap with baseline, temperature differs significantly from baseline (P <0.05). A mixed-effect model describing the effect of phase was used. B. Boxplot describing arterial lactate levels throughout the intervention. Baseline = after induction of anaesthesia but before start of the operation, H0 = 30 minutes before HIPEC, H1 and H2 = 30 and 60 minutes after start of HIPEC, H3 = end of HIPEC, End = 5 minutes before end of the operation. HIPEC, hyperthermic intraperitoneal chemotherapy.