Table 1 Correlations of GRP78 and HPA expression in oral cancer with the clinicopathological parameters
Variable | n | % | GRP78 | P | HPA | P | ||
|---|---|---|---|---|---|---|---|---|
Positive | Negative | Positive | Negative | |||||
Tissue | 0.003 | 0.033 | ||||||
Normal | 10 | 17.9 | 0 | 10 | 0 | 10 | ||
OSCC | 46 | 82.1 | 27 | 19 | 19 | 27 | ||
Gender | 0.358 | 0.555 | ||||||
Male | 37 | 80.4 | 20 | 17 | 14 | 23 | ||
Female | 9 | 19.6 | 7 | 2 | 5 | 4 | ||
Age | 0.606 | 0.055 | ||||||
≤60 | 27 | 58.7 | 15 | 12 | 8 | 19 | ||
>60 | 19 | 41.3 | 12 | 7 | 11 | 8 | ||
Tumor size | 0.001 | 0.036 | ||||||
≤3.1 | 23 | 50.0 | 8 | 15 | 6 | 17 | ||
>3.1 | 23 | 50.0 | 19 | 4 | 13 | 10 | ||
Tumor stage | 0.001 | 0.000 | ||||||
T1-T2 | 31 | 67.4 | 13 | 18 | 7 | 24 | ||
T3-T4 | 15 | 32.6 | 14 | 1 | 12 | 3 | ||
Lymphatic metastasis | 0.000 | 0.012 | ||||||
N0 | 27 | 58.7 | 10 | 17 | 7 | 20 | ||
N1-3 | 19 | 41.3 | 17 | 2 | 12 | 7 | ||
Distant metastasis | 0.033 | 0.000 | ||||||
M0 | 35 | 76.1 | 17 | 18 | 8 | 27 | ||
M1 | 11 | 23.9 | 10 | 1 | 11 | 0 | ||
TNM stage | 0.000 | 0.000 | ||||||
I-II | 23 | 50.0 | 6 | 17 | 3 | 20 | ||
III-IV | 23 | 50.0 | 21 | 2 | 16 | 7 | ||
Histologic grade | 0.018 | 0.016 | ||||||
G1-G2 | 12 | 26.1 | 11 | 1 | 9 | 3 | ||
G3-G4 | 34 | 73.9 | 16 | 18 | 10 | 24 | ||
Cigarette smoking | 0.246 | 0.180 | ||||||
Yes | 39 | 84.8 | 21 | 18 | 14 | 25 | ||
No | 7 | 15.2 | 6 | 1 | 5 | 2 | ||
Alcohol drinking | 0.787 | 1.000 | ||||||
Yes | 36 | 78.3 | 22 | 14 | 15 | 21 | ||
No | 10 | 21.7 | 5 | 5 | 4 | 6 | ||