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Table 3 Treatment outcomes for patients associated with molecular marker status

From: A pilot study: sequential gemcitabine/cisplatin and icotinib as induction therapy for stage IIB to IIIA non-small-cell lung adenocarcinoma

Patient

Gender

Smoking status

EGFR status

ERCC1

RRM1

CR

   

Biopsy

SS

Pre-Pl

Post-Pl

mRNA

IHC

mRNA

IHC

 

1

M

Current

Wild

Ex19 Del

Wild

Wild

+

(−)

+++

(+)

PR

2

F

Never

Wild

/

Wild

/

/

/

/

/

SD

3

F

Never

Wild

/

Wild

/

/

/

/

/

SD

4

M

Current

/

Wild

Wild

Wild

+

(−)

+++

(−)

SD

5

F

Never

Wild

Wild

Wild

Wild

+

(−)

+++

(−)

PR

6

F

Never

Wild

Wild

Wild

Wild

+

(−)

+++

(+)

PR

7

F

Never

Wild

/

Wild

/

/

/

/

/

SD

8

F

Never

Ex19 Del

Ex19 Del

Wild

Wild

+

(−)

+++

(+)

PR

9

M

Current

Wild

/

Wild

/

/

/

/

/

PD

10

M

Current

Ex19 Del

Ex19 Del

Wild

Wild

++

(−)

++

(−)

PR

11

M

Former

/

/

Wild

/

/

/

/

/

SD

  1. CR, clinical response; EGFR, epidermal growth factor receptor; F, female; IHC, immunohistochemistry; M, male; PD, progressive disease; post-Pl: post-treatment plasma; PR, partial response; pre-Pl: pre-treatment plasma; SD, stable disease; SS, surgical specimen.