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Table 1 The proliferation of HVECs was inhibited by urea, urea liposome, and urea immunoliposome treatment

From: Urea immunoliposome inhibits human vascular endothelial cell proliferation for hemangioma treatment

Culture period (day)

Cell number (X ± S, ×104)

Medium

Liposome

2.6% urea

2.6% urea liposome

2.6% urea immunoliposome

0

1.00 ± 0.15

1.00 ± 0.14

1.00 ± 0.05

1.00 ± 0.28

1.00 ± 0.24

1

3.90 ± 0.19

3.62 ± 0.17

5.00 ± 0.26

2.25 ± 0.11*

1.75 ± 0.09**

2

5.43 ± 0.45

5.89 ± 0.24

6.30 ± 0.86

4.64 ± 0.32*

1.40 ± 0.11***

3

11.6 ± 0.50

10.25 ± 0.72

9.98 ± 0.28

5.16 ± 0.64**

1.40 ± 0.07***

4

16.01 ± 0.92

17.50 ± 1.12

16.19 ± 1.38

6.56 ± 1.02***

0.86 ± 0.04***

5

25.73 ± 1.07

26.5 ± 2.41

22.31 ± 1.15*

9.10 ± 0.52***

0.27 ± 0.03***

6

34.65 ± 1.73

34.25 ± 1.42

27.30 ± 2.13*

10.24 ± 0.73***

0.19 ± 0.01***

7

46.50 ± 3.57

42.60 ± 4.21

32.46 ± 2.45**

8.14 ± 0.23***

0.08 ± 0.0038***

8

47.6 ± 2.10

45.00 ± 3.20

34.30 ± 3.30**

7.61 ± 0.003***

0.04 ± 0.0021***

  1. HVECs were treated as in Figure 3. The daily cell numbers are shown as the mean ± standard error in the mean and are representative of three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.0001, compared with the control.