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Table 1 The proliferation of HVECs was inhibited by urea, urea liposome, and urea immunoliposome treatment

From: Urea immunoliposome inhibits human vascular endothelial cell proliferation for hemangioma treatment

Culture period (day) Cell number (X ± S, ×104)
Medium Liposome 2.6% urea 2.6% urea liposome 2.6% urea immunoliposome
0 1.00 ± 0.15 1.00 ± 0.14 1.00 ± 0.05 1.00 ± 0.28 1.00 ± 0.24
1 3.90 ± 0.19 3.62 ± 0.17 5.00 ± 0.26 2.25 ± 0.11* 1.75 ± 0.09**
2 5.43 ± 0.45 5.89 ± 0.24 6.30 ± 0.86 4.64 ± 0.32* 1.40 ± 0.11***
3 11.6 ± 0.50 10.25 ± 0.72 9.98 ± 0.28 5.16 ± 0.64** 1.40 ± 0.07***
4 16.01 ± 0.92 17.50 ± 1.12 16.19 ± 1.38 6.56 ± 1.02*** 0.86 ± 0.04***
5 25.73 ± 1.07 26.5 ± 2.41 22.31 ± 1.15* 9.10 ± 0.52*** 0.27 ± 0.03***
6 34.65 ± 1.73 34.25 ± 1.42 27.30 ± 2.13* 10.24 ± 0.73*** 0.19 ± 0.01***
7 46.50 ± 3.57 42.60 ± 4.21 32.46 ± 2.45** 8.14 ± 0.23*** 0.08 ± 0.0038***
8 47.6 ± 2.10 45.00 ± 3.20 34.30 ± 3.30** 7.61 ± 0.003*** 0.04 ± 0.0021***
  1. HVECs were treated as in Figure 3. The daily cell numbers are shown as the mean ± standard error in the mean and are representative of three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.0001, compared with the control.