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Table 1 Summary of the clinical features reported for undifferentiated liver embryonal sarcoma in patients aged over 45 years

From: Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus

No. Reference Publication year Sex Age(years) Symptoms and signs Laboratory findings Location Size (cm) Surgery Adjuvant therapy Recurrence Follow-up, duration Co-morbidity or past history
1 Mattila et al. [4] 1974 F 68 RUQA pain, hepatomegaly ↑ALP, LDH, Bilirubin R + L 20 × 18 × 15 Rx ext hep None Yes DOD, 5 months None
2 Tanner et al. [5] 1978 F 66 RUQA pain, vomiting, diarrhea, weight loss, fever, hepatomegaly ↑ALP, GGT R NA HA ligation + pump 5-FU - AWD, 8 months CHD
3 Chang et al. [6] 1983 F 55 RUQA pain, weight loss, diarrhea, hepatomegaly ↑ALP L 10 × 10 × 8 Left lob CAV No ANED, 12 months CREST syndrome
4 Ellis et al. [7] 1983 F 86 RUQA pain, RUQA mass Normal R 18 × 12 × 12 Tumorectomy None Yes DOD, 2 months None
5 Forbes et al. [8] 1987 M 69 RUQA pain, nausea, weight loss, general malaise Normal NA NA None RT - DOD, 10 months Malaria and resection for colonic carcinoma
6 Forbes et al. [8] 1987 F 49 RUQA pain, nausea, weight loss, general malaise NA NA NA None None - DOD None
7 Grazi et al. [9] 1996 F 60 RUQA mass, dyspepsia Normal R 22 Rx hep None Yes DOD, 10 months NA
8 Nishio et al.[3] 2003 F 49 RUQA pain, general fatigue NA R 14 × 8 × 8 Rx lob Adm + Dtic Yes DOD, 29 months None
9 Nishio et al. [3] 2003 M 62 RUQA pain NA L 10 × 9 × 7 Left lob None No ANED, 10 months NA
10 Lepreux et al. [10] 2005 F 51 RUQA pain, dyspnea, edema of the lower limbs Normal R 18 × 16 Liver biopsy CAV NA DOD, 2 months (died from septic shock and acute pneumopathy) NA
11 Lepreux et al. [10] 2005 F 49 RUQA pain, increased abdominal girth Normal L 15 × 13 Left lob MAID, RT No ANED, 6 months NA
12 Agaram et al. [11] 2006 F 50 NA NA NA 17 NA NA No ANED, 8 months NA
13 Scudiere et al. [12] 2006 F 51 NA ↑ALT, AST R 23 × 16 × 7 Rx lob NA NA NA Community-acquired pneumonia
14 Ma et al. [13] 2008 F 61 RUQA pain Normal R 12 × 9 × 8 Rx hep None NA DOD, 8 months None
15 Yang et al. [14] 2009 M 46 Upper abdominal pain, fever, mass, hepatomegaly ↑ALT, GGT, AFP HBeAb(+), HBcAb(+) R 6 × 6 × 5 Rx hep NA NA NA Hepatitis B cirrhosis and HCC in the left lobe
16 Yang et al. [14] 2009 M 54 Upper abdominal pain, fever, mass, hepatomegaly ↑ALT, AST, GGT R 13 × 12 × 12 Rx hep NA NA NA None
17 Kullar et al. [15] 2009 F 52 RUQA pain, RUQA mass ↑ALP R 18 × 12 × 8 Rx ext hep Adm + Ifs Yes DOD, 12 months Chemotherapy for ovarian cancer
18 Yoon et al. [16] 2010 F 53 Abdominal discomfort Normal R 13 × 12 × 8 Rx hep None No ANED, 6 months None
19 Massani et al. [17] 2010 F 47 Upper abdominal pain Normal R 8 Rx hep Epi + Ifs; TACE with Epi Yes AWD, 29 months None
20 Li et al. [18] 2010 M 63 RUQA pain, fever ↑ALP R 20 × 15 × 15 Rx hep NA Yes DOD, 18 months None
21 Li et al. [18] 2010 M 56 RUQA pain ↑ALP, ALT, AST, GGT R 13 × 12 Rx hep TACE with lipiodol, Epi, hydroxycamptothecin Yes DOD, 28 months None
22 Gasljevic et al. [19] 2011 F 58 Asymptomatic NA R 11 × 8 Rx lob Cysplatin + 5-FU + Vcr No DOD, 10 months (died from unrelated cause, B-ALL) None
23 Kim et al. [20] 2011 F 47 Abdominal mass ↑CA-125 L 12 × 10 Left hep MAID, RT Yes AWD, 48 months None
24 Legou et al. [21] 2012 F 61 Upper abdominal pain, RUQA mass ↑ALP, ALT, AST L 27 × 22 × 10 Tumorectomy NA NA NA None
25 Tanaka et al. [22] 2012 F 53 Asymptomatic Liver function tests were slightly abnormal R 12 × 11 × 7 Rx lob None Yes DOD, 36 months Multiple sclerosis
26 Tucker et al. [23] 2012 F 74 Abdominal pain and fullness, back pain Normal L 18 × 15 × 13 Left hep None No ANED, 9 months NA
27 Lightfood et al. [24] 2012 F 78 Abdominal mass Normal R 16 Partial right hepatectomy None No ANED, 6 months NA
28 This report 2013 F 49 Upper abdominal pain Normal R 7 × 6 × 5 Rx lob Traditional Chinese medicine orally Yes DOD, 12 months SLE
  1. 5-FU, 5-fluouracil; Adm, doxorubicin; AFP, α-fetoprotein; ALP, alkaline phosphatase; ALT, alanine aminotransferase; ANED, alive with no evidence of disease; AST, aspartate aminotransferase; AWD, alive with disease; B-ALL, B-lymphoblastic leukemia; CA-125, carbohydrate antigen 125; CAV, cyclophosphamide + Adm + Vcr; CHD, coronary heart of disease; CREST syndrome, calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia syndrome; DOD, dead of disease-related cause; Dtic, decarbazine; Epi, epirubicin; F, female; GGT, γ-glutamyl transpeptidase; HA, hepatic artery; HCC, hepatocellular carcinoma; Ifs, ifosfamide; L, left; Left hep, left hepatectomy; Left lob, left lobectomy; M, male; MAID, Adm + Ifs + Dtic + methylprednisolone; NA, not available; R, right; RT, radiation therapy; RUQA, right upper quadrant abdominal; Rx ext hep, extended right hepatectomy; Rx hep, right hepatectomy; Rx lob, right lobectomy; SLE, systemic lupus erythematosus; TACE, transcatheter arterial chemoembolization; Vcr, vincristine.