Table 1 Summary of the clinical features reported for undifferentiated liver embryonal sarcoma in patients aged over 45 years
No. | Reference | Publication year | Sex | Age(years) | Symptoms and signs | Laboratory findings | Location | Size (cm) | Surgery | Adjuvant therapy | Recurrence | Follow-up, duration | Co-morbidity or past history |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Mattila et al. [4] | 1974 | F | 68 | RUQA pain, hepatomegaly | ↑ALP, LDH, Bilirubin | R + L | 20 × 18 × 15 | Rx ext hep | None | Yes | DOD, 5 months | None |
2 | Tanner et al. [5] | 1978 | F | 66 | RUQA pain, vomiting, diarrhea, weight loss, fever, hepatomegaly | ↑ALP, GGT | R | NA | HA ligation + pump | 5-FU | - | AWD, 8 months | CHD |
3 | Chang et al. [6] | 1983 | F | 55 | RUQA pain, weight loss, diarrhea, hepatomegaly | ↑ALP | L | 10 × 10 × 8 | Left lob | CAV | No | ANED, 12 months | CREST syndrome |
4 | Ellis et al. [7] | 1983 | F | 86 | RUQA pain, RUQA mass | Normal | R | 18 × 12 × 12 | Tumorectomy | None | Yes | DOD, 2 months | None |
5 | Forbes et al. [8] | 1987 | M | 69 | RUQA pain, nausea, weight loss, general malaise | Normal | NA | NA | None | RT | - | DOD, 10 months | Malaria and resection for colonic carcinoma |
6 | Forbes et al. [8] | 1987 | F | 49 | RUQA pain, nausea, weight loss, general malaise | NA | NA | NA | None | None | - | DOD | None |
7 | Grazi et al. [9] | 1996 | F | 60 | RUQA mass, dyspepsia | Normal | R | 22 | Rx hep | None | Yes | DOD, 10 months | NA |
8 | Nishio et al.[3] | 2003 | F | 49 | RUQA pain, general fatigue | NA | R | 14 × 8 × 8 | Rx lob | Adm + Dtic | Yes | DOD, 29 months | None |
9 | Nishio et al. [3] | 2003 | M | 62 | RUQA pain | NA | L | 10 × 9 × 7 | Left lob | None | No | ANED, 10 months | NA |
10 | Lepreux et al. [10] | 2005 | F | 51 | RUQA pain, dyspnea, edema of the lower limbs | Normal | R | 18 × 16 | Liver biopsy | CAV | NA | DOD, 2 months (died from septic shock and acute pneumopathy) | NA |
11 | Lepreux et al. [10] | 2005 | F | 49 | RUQA pain, increased abdominal girth | Normal | L | 15 × 13 | Left lob | MAID, RT | No | ANED, 6 months | NA |
12 | Agaram et al. [11] | 2006 | F | 50 | NA | NA | NA | 17 | NA | NA | No | ANED, 8 months | NA |
13 | Scudiere et al. [12] | 2006 | F | 51 | NA | ↑ALT, AST | R | 23 × 16 × 7 | Rx lob | NA | NA | NA | Community-acquired pneumonia |
14 | Ma et al. [13] | 2008 | F | 61 | RUQA pain | Normal | R | 12 × 9 × 8 | Rx hep | None | NA | DOD, 8 months | None |
15 | Yang et al. [14] | 2009 | M | 46 | Upper abdominal pain, fever, mass, hepatomegaly | ↑ALT, GGT, AFP HBeAb(+), HBcAb(+) | R | 6 × 6 × 5 | Rx hep | NA | NA | NA | Hepatitis B cirrhosis and HCC in the left lobe |
16 | Yang et al. [14] | 2009 | M | 54 | Upper abdominal pain, fever, mass, hepatomegaly | ↑ALT, AST, GGT | R | 13 × 12 × 12 | Rx hep | NA | NA | NA | None |
17 | Kullar et al. [15] | 2009 | F | 52 | RUQA pain, RUQA mass | ↑ALP | R | 18 × 12 × 8 | Rx ext hep | Adm + Ifs | Yes | DOD, 12 months | Chemotherapy for ovarian cancer |
18 | Yoon et al. [16] | 2010 | F | 53 | Abdominal discomfort | Normal | R | 13 × 12 × 8 | Rx hep | None | No | ANED, 6 months | None |
19 | Massani et al. [17] | 2010 | F | 47 | Upper abdominal pain | Normal | R | 8 | Rx hep | Epi + Ifs; TACE with Epi | Yes | AWD, 29 months | None |
20 | Li et al. [18] | 2010 | M | 63 | RUQA pain, fever | ↑ALP | R | 20 × 15 × 15 | Rx hep | NA | Yes | DOD, 18 months | None |
21 | Li et al. [18] | 2010 | M | 56 | RUQA pain | ↑ALP, ALT, AST, GGT | R | 13 × 12 | Rx hep | TACE with lipiodol, Epi, hydroxycamptothecin | Yes | DOD, 28 months | None |
22 | Gasljevic et al. [19] | 2011 | F | 58 | Asymptomatic | NA | R | 11 × 8 | Rx lob | Cysplatin + 5-FU + Vcr | No | DOD, 10 months (died from unrelated cause, B-ALL) | None |
23 | Kim et al. [20] | 2011 | F | 47 | Abdominal mass | ↑CA-125 | L | 12 × 10 | Left hep | MAID, RT | Yes | AWD, 48 months | None |
24 | Legou et al. [21] | 2012 | F | 61 | Upper abdominal pain, RUQA mass | ↑ALP, ALT, AST | L | 27 × 22 × 10 | Tumorectomy | NA | NA | NA | None |
25 | Tanaka et al. [22] | 2012 | F | 53 | Asymptomatic | Liver function tests were slightly abnormal | R | 12 × 11 × 7 | Rx lob | None | Yes | DOD, 36 months | Multiple sclerosis |
26 | Tucker et al. [23] | 2012 | F | 74 | Abdominal pain and fullness, back pain | Normal | L | 18 × 15 × 13 | Left hep | None | No | ANED, 9 months | NA |
27 | Lightfood et al. [24] | 2012 | F | 78 | Abdominal mass | Normal | R | 16 | Partial right hepatectomy | None | No | ANED, 6 months | NA |
28 | This report | 2013 | F | 49 | Upper abdominal pain | Normal | R | 7 × 6 × 5 | Rx lob | Traditional Chinese medicine orally | Yes | DOD, 12 months | SLE |