Evaluation of the immune factors in the tumor environment before and after the treatment of cetuximab combined with chemotherapy

Table 4 The correlation of change of expression of immune factors, clinical efficacy, and treatment number was examined by the Spearman’s correlation analysis

		Treatment number	Clinical efficacy	CD8	IL-2	VEGF	TNF-α
Clinical efficacy	Correlation coefficient	0.479
	P value	0.115
	Sample size	12
CD8	Correlation coefficient	0.027	−0.250
	P value	0.935	0.433
	Sample size	12	12
IL-2	Correlation coefficient	−0.585	−0.120	−0.239
	P value	0.046^a	0.711	0.454
	Sample size	12	12	12
VEGF	Correlation coefficient	0.171	0.000	−0.167	−0.080
	P value	0.594	1.000	0.605	0.806
	Sample size	12	12	12	12
TNF-α	Correlation coefficient	0.048	−0.112	0.391	0.000	0.050
	P value	0.883	0.729	0.208	1.000	0.878
	Sample size	12	12	12	12	12
TGF-β	Correlation coefficient	−0.527	−0.684	−0.114	0.218	0.184	0.361
	P value	0.078	0.014^a	0.724	0.496	0.568	0.249
	Sample size	12	12	12	12	12	12

ISSN: 1477-7819