Figure 3
Histochemical examination of the tumour (H & E staining). (A) The area of small cell carcinoma showed small or round cells, with finely granular, hyperchromatic nuclei, inconspicuous nucleoli and scanty cytoplasm. Nuclear moulding and cord-like appearing cells were identified. The area of urothelial carcinoma in situ overlay the area of small cell carcinoma (200×). (B) Urothelial carcinoma cells invading the lamina propria (100×). (C) Juxtaposition of areas of small cell carcinoma and urothelial carcinoma, showing the small cell carcinoma invading the lamina propria as far as the periureteric adipose tissue and the overlying focal urothelial carcinoma in situ (40×). (D) Cross-sectional view of ureter showing the small cell carcinoma invading the ureter and periureteric fat and protruding into the ureteral lumen (12.5×).