Double-positive expression of high-mobility group box 1 and vascular endothelial growth factor C indicates a poorer prognosis in gastric cancer patients

Table 1 Association between the expression of vascular endothelial growth factor C (VEGF-C) and high-mobility group box 1 (HMGB1) with clinicopathological characteristics of patients with gastric cancer

Clinicopathological characteristics	No.	HMGB1		Ratio (%)	P value	VEGF-C		Ratio (%)	P value
		Positive	Negative			Positive	Negative
Total	166	81	85	48.80		88	78	53.01
Age at surgery:
<60	84	45	39	53.57	0.213	47	37	55.95	0.442
≥60	82	36	46	43.90		41	41	50.00
Gender:
Male	113	59	54	52.21	0.198	59	54	55.66	0.763
Female	53	22	31	41.51		29	24	59.18
Histological type:
Adenocarcinoma	135	62	73	45.93	0.123	69	66	51.11	0.306
Other	31	19	12	61.29		19	12	61.29
Tumor size:
<4 cm	83	30	53	36.14	0.001	32	51	38.55	<0.001
≥4 cm	83	51	32	61.45		56	27	67.47
Borrmann type:
I+II	35	16	19	45.71	0.681	17	18	48.57	0.553
III+IV	131	65	66	49.62		71	60	54.20
Differentiation:
Low	113	56	57	49.56	0.774	58	55	51.33	0.525
Moderate andhigh	53	25	28	43.24		30	23	54.05
pT stage:
pT1 to pT2	34	9	25	26.47	0.003	10	24	29.41	0.002
pT3 to pT4	132	72	60	54.55		78	54	59.09
Distant metastasis:
M0	122	53	69	43.44	0.022	57	65	46.72	0.007
M1	44	28	16	63.64		31	13	70.45
TNM stage:
Stage I+II	61	17	44	27.87	<0.001	17	44	27.87	<0.001
Stage III+IV	105	64	41	60.95		71	34	67.62
Nodal status:
pN0	63	19	44	30.16	<0.001	21	42	33.33	<0.001
pN1 to pN3	103	62	41	60.19		67	36	65.05

ISSN: 1477-7819