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Table 2 Expression levels of cytochrome C, caspase-3 and caspase-9 ※

From: Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer

Group

Cytochrome C

Caspase-9

Capase-3

control

1.7542 ± 1.1869

2.1837 ± 1.3627

1.7562 ± 1.2761

5-FU

3.7397 ± 1.2963a

3.0527 ± 1.0667a

2.9242 ± 1.6728a

celecoxib

5.6286 ± 1.0629 a

5.9782 ± 1.2869 a

6.7197 ± 1.1869 a

5-FU + celecoxib

7.9784 ± 1.1265 a,b,c

7.7281 ± 1.0691 a,b,c

7.9942 ± 1.0014 a,b,c

  1. Note: ※ Values represent the mean ± SD; a There were significant differences in the protein expression of cytochrome C, caspase-9 and caspase-3 between each treatment group compared with the control group, P <0.05. b Compared with the 5-FU group, the protein expression of cytochrome C, caspase-9 and caspase-3 was significantly higher in the 5-FU + celecoxib group, P <0.05. C Compared with the celecoxib group, the protein expression of cytochrome C, caspase-9 and caspase-3 was also significantly higher in the 5-FU + celecoxib group, P <0.05.
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World Journal of Surgical Oncology

ISSN: 1477-7819

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