Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma

Table 3 The relationship between CCT2 and PDIA3 expression and clinicopathological features of gallbladder AC

Clinical and pathological features	Case number	CCT2			PDIA3
Clinical and pathological features	Case number	Positive number (%)	χ²	P	Positive number (%)	χ²	P
Gender
male	26	14(53.8)	0.000	0.990	14(53.8)	0.090	0.764
female	54	29(53.7)	0.000	0.990	31(57.4)	0.090	0.764
≤ 45
> 45	16	5(31.3)	4.073	0.044	7(43.8)	1.270	0.260
Degree of differentiation^a	64	38(59.4)	4.073	0.044	38(59.4)	1.270	0.260
well-differentiated
moderately-Differentiated	27	10(37.0)	5.326	0.070	12 (44.4)	11.840	0.000
poorly-differentiated	25	14(56.0)			10(40.0)
Tumor maximum diameter (cm)	28	19(67.9)			23(82.1)
≤ 3 cm
> 3 cm	50	22(44.0)	5.099	0.024	23(46.0)	5.692	0.017
Gallbladder stones	30	21(70.0)	5.099	0.024	22(73.3)	5.692	0.017
no
yes	42	19(45.2)	2.577	0.108	25(59.5)	0.343	0.558
TNM stage	38	24(63.2)			20(52.6)
I + II
III	21	6(28.6)			7(33.3)
IV	38	20(52.6)	11.625	0.003	20(52.6)	12.092	0.002
Lymph node metastasis	21	17(81.0)			18(85.7)
no
yes	30	10(33.3)	8.049	0.004	12(40.0)	5.150	0.020
Invasion	50	33(66.0)	8.049	0.004	33(66.0)	5.150	0.020
no
yes	31	11(35.5)	6.793	0.009	14(45.2)	2.529	0.112
Surgical	49	32(65.3)	6.793	0.009	31(63.3)	2.529	0.112
radical
palliative	26	8(30.8)	11.140	0.004	10(38.5)	7.940	0.019
biopsy	28	15(53.6)	11.140	0.004	15(53.6)	7.940	0.019
≤ 45	26	20(76.9)			20(76.9)

^aComparison between well-differentiated and poorly-differentiated adenocarcinoma: χ²_CCT2 = 5.24, P = 0.022; χ²_PDIA3 = 8.44, P = 0.004; Comparison between moderately-differentiated and poorly-differentiated adenocarcinoma: χ²_CCT2 = 0.79, P = 0.374; χ²_PDIA3 = 9.98, P = 0.002.

ISSN: 1477-7819