Overexpression of HSPA2 is correlated with poor prognosis in esophageal squamous cell carcinoma

Table 2 Univariate survival analysis of overall survival and disease-free survival in 120 patients with ESCC

Features	Overall survival		Disease-free survival
	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age (≤60/>60 years)	0.713 (0.456 to 1.116)	0.139	0.745 (0.493 to 1.125)	0.162
Gender (female/male)	0.915 (0.553 to 1.513)	0.728	0.975 (0.624 to 1.525)	0.913
Drinking (yes/no)	1.043 (0.670 to 1.622)	0.853	1.017 (0.681 to 1.518)	0.935
Tumor site (upper + lower/middle)	1.347 (0.797 to 2.277)	0.266	1.216 (0.768 to 1.926)	0.405
Grade (G2 + G3 + G4/G1)	1.137 (0.739 to 1.749)	0.559	1.070 (0.723 to 1.584)	0.735
Primary tumor (T3 + T4/T1 + T2)	2.157 (1.380 to 3.372)	0.001^a	1.872 (1.256 to 2.791)	0.002^a
TNM stage (III/I + II)	21.177 (11.057 to 40.561)	<0.001^a	15.085 (8.320 to 27.350)	<0.001^a
Lymph node metastases (−/+)	0.572 (0.369 to 0.887)	0.012^a	0.625 (0.418 to 0.935)	0.022^a
HSPA2 expression (positive/negative)	3.557 (1.827 to 6.922)	<0.001^a	2.901 (1.721 to 4.888)	<0.001^a

^aP values considered statistically significant at <0.05. CI, confidence interval; ESCC, esophageal squamous cell carcinoma; G, grade; N, lymph node metastases; T, primary tumor. Drinking alcohol is defined as: average amount of drinking alcohol is 50 grams or more per day, and period of drinking continues to 1 year or more. Drinking alcohol parameter: amount of drinking/ day × years of drinking.

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