Table 2 Univariate Cox regression analysis of potential prognostic factors for 177 osteosarcoma patients
Clinical characteristics | OS | DFS | ||
|---|---|---|---|---|
Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P | |
Histological type | ||||
Osteoblastic | 4.090(1.491,11.251) | 0.006 | 3.524(1.283,9.677) | 0.015 |
Chondroblastic | 2.741(0.882,8.521) | 0.081 | 2.140(0.689,6.648) | 0.188 |
Fibroblastic | 1.573(0.422,5.862) | 0.500 | 1.231(0.331,4.588) | 0.756 |
Dilated blood vessels | 3.313(0.933,11.767) | 0.064 | 3.249(0.913,11.555) | 0.069 |
Others | 1.000 | 1.000 | ||
Tumor size | ||||
< 6 cm | 1.000 | 1.000 | ||
≥ 6 cm | 2.112(1.374,3.246) | 0.001 | 1.968(1.282,3.020) | 0.002 |
Surgery type | ||||
Amputation | 1.000 | 1.000 | ||
Limb sparing | 0.439(0.292,0.660) | < 0.01 | 0.501(0.333,0.753) | 0.001 |
Post-operative chemotherapy | ||||
Not standard a | 1.000 | 1.000 | ||
Standard b | 0.612(0.390,0.960) | 0.033 | 0.646(0.412,1.013) | 0.057 |
Pre-ALP | ||||
Normal | 1.000 | 1.000 | ||
High | 1.938(1.099,3.418) | 0.022 | 1.985(1.126,3.500) | 0.018 |
Very high | 3.402(1.915,6.044) | < 0.01 | 3.267(1.840,5.800) | < 0.01 |
Lung metastasis | ||||
No | 1.000 | 1.000 | ||
Yes | 2.380(1.531,3.698) | < 0.01 | 5.562(3.422,9.040) | < 0.01 |
Local recurrence | ||||
No | 1.000 | 1.000 | ||
Yes | 1.255(0.652,2.418) | 0.496 | 2.274(1.168,4.427) | 0.016 |