High-pressure intrapleural chemotherapy: feasibility in the pig model

Table 1 Synthesis of methods and results of all animals treated.

Pig	Side	Pneumonectomy	Chemotherapy	Pressure (cmH₂0)/time (min)	Outcomes
1 2	Left	No	No	15/5	Left to right pleural filling
3 4	Right	No	No	15/30	Well tolerated
5 6	Right	No	No	20/30	Moderate haemodynamic changes
7	Right	No	No	20/60
8	Right	No	No	25/5	Major but reversible haemodynamic instability
9 10	Right	No	No	25/5	Peroperative death
11	Right			15/15	Controlateral breach
12		Before infusion	No	20/5	Peroperative death
13				15/15	Major but reversible haemodynamic instability Postoperative death
14 15 16	Right	After infusion	No	20/40	Moderate haemodynamic changes Postoperative death
17 18 19 20 21	Right	No	Cisplatin (30 mg/l) Gemcitabin (100 mg/l)	20/60	Moderate haemodynamic changes No morbidity Pleurodesis

Moderate haemodynamic changes are defined as a decrease in arterial pressure and cardiac output requiring vascular resuscitation. When haemodynamic modifications persisted, they were major, and reversible if emptying saved the animal, or lethal if not.

ISSN: 1477-7819