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Table 1 Synthesis of methods and results of all animals treated.

From: High-pressure intrapleural chemotherapy: feasibility in the pig model

Pig Side Pneumonectomy Chemotherapy Pressure (cmH20)/time (min) Outcomes
1
2
Left No No 15/5 Left to right pleural filling
3
4
Right No No 15/30 Well tolerated
5
6
Right No No 20/30 Moderate haemodynamic changes
7 Right No No 20/60  
8 Right No No 25/5 Major but reversible haemodynamic instability
9
10
Right No No 25/5 Peroperative death
11 Right    15/15 Controlateral breach
12   Before infusion No 20/5 Peroperative death
13     15/15 Major but reversible haemodynamic instability
Postoperative death
14
15
16
Right After infusion No 20/40 Moderate haemodynamic changes
Postoperative death
17
18
19
20
21
Right No Cisplatin
(30 mg/l)
Gemcitabin
(100 mg/l)
20/60 Moderate haemodynamic changes
No morbidity
Pleurodesis
  1. Moderate haemodynamic changes are defined as a decrease in arterial pressure and cardiac output requiring vascular resuscitation. When haemodynamic modifications persisted, they were major, and reversible if emptying saved the animal, or lethal if not.