The bidirectional interation between pancreatic cancer and diabetes

Table 1 The potential mechanisms of diabetes in PanCa

Parameters		Role in PanCa	Refs
Pancreatic duct	Enlargement	Mechanical obstruction	[24]
	Replication increased	Predisposing factor	[25]
Hyperinsulinism and insulin resistance	Post-insulin receptor defect	Impaired glycogen synthesis and storage	[27]
	Plasma glucagon levels and IAPP	Early development of PanCa	[28]
	Polymorphism of -23HphI (A/T)	Pathogenesis of PanCa	[29]
Tumor size	Increased	Decreased postresection survival	[31]
		Enhanced growth	[32]
Genetic variants	HK2 R844K GA/AA genotype	Increased risk	[33]
	K-ras codon 12 mutations	Increased risk	[34]

ISSN: 1477-7819