Table 1 Summarized data of patients with GIP during TKI treatment for RCC
No. | Age | Type of tumor | Metastatic site | Previous treatment | Present treatment | With palliative adiation (Gy) | Month after TKI (mo) | Initial symptom | Perforation location | Treatment | Pathological findings in perforation | Follow up | Author |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | 50 | RCC | Lung | Inferon | Sunitinib (50) | (−) | 6 | Abdominal pain | Ascending colon | Surgery | No malignancy | Alive | Hoshino et al. |
2. | 60 | RCC | Right Pelvis bone | Inferon | Sunitinib (50) | (−) | 0 | Abdominal pain | Jejunum | Surgery | Cancer metastases | Death after 3- mo | Hoshino et al. |
3. | Unknown | RCC | Lung | High dose Interleukin- 2 | Sunitinib (50) | (−) | 13 | Abdominal pain | Ascending | Surgery | No malignancy | Unknown | Flaig et al. |
4. | Unknown | RCC | Lung | High-dose Interleukin-2 | Sunitinib (37.5) | (−) | 20 | Abdominal pain | Ascending colon | Conservative | Unknown | Unknown | Flaig et al. |
5. | 61 | RCC | Skin Lung spine | (−) | Sunitinib (800) | L3-5 (8) | 2 | Abdominal pain | Transverse colon Sigmoid colon | Conservative | No malignancy | Death after 1- day | Peters |
6. | 48 | RCC | Lung Lymph node Multiple bone | Interferon | Sorafenib (800) | Th3, L2-4 (30) | 14 | Abdominal pain | Sigmoid colon | Surgery | No malignancy | Death After3- mo | Our case |
7. | 61 | RCC | Lung Left femoral bone | Interferon | Sorafenib (800) | Left femoral (30) | 1 | Abdominal pain | Sigmoid colon | Surgery | No malignancy | Death after 29 days | Our case |