Immunohistochemical consistency between primary tumors and lymph node metastases of gastric neuroendocrine carcinoma

Table 3 Histology and immunohistochemical findings of both primary tumor and metastatic lymph nodes

Patient no.	Primary tumor						Lymph node metastases					Ki-6 7 labeling index (%)	Mitotic counts (/10HPF)
	Histology	Ratio of neuroendocrine cell (%)	Expression of neuroendocrine markers				Histlogy	Expression of neuroendocrine markers
			SYN	CGA	CD56	NSE		SYN	CGA	CD56	NSE
1	SC	100	3+	-	3+	3+	SC	3+	-	3+	3+	60	60 to 70
2	LC	100	3+	3+	2+	1+	LC	1+	3+	1+	2+	20	20
3	LC	100	3+	-	2+	3+						80	80 to 90
4	LC > tub2	90	3+	3+	3+	-	LC	3+	3+	2+	-	30	80 to 90
5	LC	100	3+	-	3+	-	LC	3+	-	3+	-	70	100 to 110
6	LC > tub2 > por1	60	3+	3+	3+	1+	pure Ad	2+	-	-	-	70	20
							LC + Ad	3+	2+	1+	-
7	SC	100	3+	-	2+	3+						80	100 to 110

Expression positivity was defined as follows; - (<5%), 1+ (5 to 9%), 2+ (10 to 49%), and 3+ (over 50%). Ad, adenocarcinoma; CGA, chromogranin A; HPF, high power fields; LC, large cell; NSE, neuron-specific enolase; SC, small cell; SYN, synaptophysin.

ISSN: 1477-7819