Table 1 Average estimates of apoptotic activity, and balance between proliferative and apoptotic activity in BCs, in different subgroups of 130 Libyan female BC patients
Group | Number of patients | AI (SD) | P value | SMI/AI (SD) | P value |
|---|---|---|---|---|---|
Whole material | 130 | 12.8 (9.6) | 2.8 (2.0) | ||
Age groups | |||||
<40 | 49 | 13.3 (9.5) | 2.9 (2.2) | ||
40-49 | 32 | 9.9 (9.9) | 0.12 | 2.4 (1.5) | 0.38 |
≥50 | 49 | 14.3 (9.4) | 3.0 (2.0) | ||
Menopausal status | |||||
Premenopausal | 80 | 12.07 (9.7) | 2.76 (2.0) | 0.54 | |
(age <50 yrs) | 0.26 | ||||
Postmenopausal | 50 | 14.05 (9.5) | 2.98 (2.0) | ||
(age ≥ 50 yrs) | |||||
Tumor size | |||||
<3 | 8 | 4.5 (5.7) | 0.011 | 2.8 (1.9) | 0.75 |
≥3 | 122 | 13.4 ( 9.6) | 3.2 | (2.2) | |
Lymph node (LN) status | |||||
LN- | 27 | 8.3 (7.0) | 0.005 | 2.5 (1.3) | 0.73 |
LN+ | 103 | 14.0 (9.9) | 2.9 (2.1) | ||
Clinical stage | |||||
Stage1 | 6 | 5.0 (5.1) | 3.0 (2.3) | ||
Stage 2 | 44 | 10.2 (6.7) | 0.009 | 2.4 (1.0) | 0.30 |
Stage 3 | 64 | 14.5 (10.5) | 2.9 (1.9) | ||
Stage 4 | 16 | 16.4 (11.4) | 3.4 (0.8) | ||
Histological grade | |||||
1 | 10 | 5.9 (5.7) | 0.035 | 2.0 (1.1) | 0.43 |
2 | 70 | 12.7 (7.4) | 3.0 (2.1) | ||
3 | 50 | 14.5 (9.0) | 2.8 (1.8) | ||
Histological type | |||||
Invasive ductal | 95 | 13.3 (10.6) | 0.61 | 2.9 (2.0) | 0.61 |
Invasive lobular | 13 | 10.8 (5.8) | 3.2 (2.5) | ||
Other carcinomas | 22 | 12.0 (6.7) | 2.8 (2.0) | ||