Papillary carcinoma thyroid with metastasis to ectopic cervical thymus
© Mushtaque et al; licensee BioMed Central Ltd. 2011
Received: 14 July 2010
Accepted: 18 February 2011
Published: 18 February 2011
Papillary carcinoma of thyroid is the most common type of thyroid neoplasm which is usually confined to the thyroid and tends to metastasize to regional lymph nodes. Distant metastasis occur in up to 15% of cases. Thymic metastasis from any malignant carcinoma is extremely rare with only four cases reported in medical literature. We report a case of papillary carcinoma of thyroid metastasizing to ectopic cervical thymus which has not been previously reported.
Papillary thyroid carcinoma is the most common neoplasm in the thyroid gland and accounts for about 70% of all thyroid carcinomas. This tumor peaks in the third or fourth decades of life, with female to male ratio ranging from 1.6:1 to 3:1 . Thyroid cancers, especially papillary carcinoma, are more often found in patients with a history of external irradiation. Papillary carcinoma of thyroid may be sub clinical or may be present with asymptomatic thyroid mass or a nodule. Other symptoms like pain, difficulty breathing or swallowing, stridor, vocal cord paralysis, haemoptysis, rapid enlargement are rare. It commonly metastasizes to regional lymph nodes, but at the time of diagnosis, 10-15% of patients have distant metastases to the bones and lungs . Other rare sites of distant metastasis are the brain, liver, and skin. 
The thymus is an important organ involved in cell-mediated immunological function, and to our knowledge, there has been only one case of papillary thyroid carcinoma with metastasis to thymus reported . We report a case of papillary carcinoma of thyroid metastasizing to ectopic cervical thymus which has not been previously reported.
Papillary carcinoma thyroid is the most common type of thyroid malignancy seen in the population especially females. This tumor usually has a good prognosis. It spreads via lymphatics and is commonly associated with enlarged cervical nodes. Bones and lungs are the usual sites of distant metastasis , however only one case of thymic metastasis has been reported till date .
As the thymus is an essential organ that controls the cellular immunity function, it has been considered almost impossible that a tumor could metastasize to the thymus. Although tumors almost never metastasize to the thymus, precise observation of the thymic structure has revealed that the thymus is not absolutely safe from tumor metastasis. The parenchyma of the thymus has a blood thymus barrier, which prevents the thymus from making direct contact with antigens or cancerous cells, thereby seemingly excluding the occurrence of cancer metastasis. However, the septum of the thymus is comprised of interlobular connective tissue with blood vessels, lymphoducts and nerves, which theoretically does not exclude the possibility of metastasis. Blood-thymus barrier is not as robust in the medulla of the organ as it is in the cortex. Also, it is not that blood-organ barrier can always prevent metastasis. Brain, eye and testis also have a blood-organ barrier and metastases in these organs have also been reported. Therefore, when the structure of the thymus is precisely analyzed, a remote possibility of the thymic metastasis from tumors is imaginable .
Embryologically, the thymus originates from the third pair of branchial pouches high in the neck during early foetal life and reaches its final destination in the mediastinum after a process of progressive decent. Rarely thymus fails to decent and appears as a remnant, implant, or accessory nodules any were along the cervical pathway, the most commonest site being at the level of thyroid gland . Adult cases of ectopic thymus are exceedingly rare due to age related involution and replacement by fibro-adipose tissue. Ectopic thymus tissue like its normal counterpart may also undergo transformation to thymic hyperplasia or even thymic neoplasia .
There are very few reports of thymic metastasis including those from breast , prostate , testis  and thyroid cancers [4, 10]. Our case represents a rarest case of papillary carcinoma thyroid with metastasis to the ectopic cervical thymus, which was found incidentally during thyroid surgery and was confirmed by histopathology and immunohistochemistry. The metastatic spread from thyroid cancer to ectopic thymus is presumed to be of haematogenous origin in absence of radiological or histological evidence of any local or nodal spread.
Although it was earlier considered almost impossible that a tumor could metastasize to the thymus, a remote possibility of the thymic metastasis from tumors is imaginable and enlargement of ectopic cervical thymus should be considered in the differential diagnosis of anterior neck swellings.
Written informed consent was obtained from the patient for publication of this case report and accompanying images.
- Mazzaferri EL: Treatment of carcinoma of follicular epithelium. In The Thyroid. 6th edition. Edited by: Braverman LE, Utiger RD. Philadelphia, Pa: Lippincott; 1991:1329–1348.
- Shaha AR, Ferlito AR: Distant metastases from thyroid and parathyroid cancer. ORL J Otorhinolaryngol Relat Spec 2001, 63:243–49.PubMed
- Martin JS: Papillary and Follicular thyroid carcinoma. The New English Journal of Medicine 1998,388(suppl 5):297–306.
- Masaya O, Hiroyasu Y, Sung-soo C, Jun N, Misaki Noriyuki: Mediastinal metastasis of the thyroid papillary carcinoma mimicking thymoma. Gen Thorac Cardiovasc Surg 2008, 56:518–520.View Article
- Sung BP, Hak HK, Hee JS, et al.: Thymic metastasis in breast cancer; A case report. Korean J Radiol 2007,8(suppl 4):360–363.
- Sang LW, Deepali G, Connelly John: Adult ectopic thymus adjacent to thyroid and parathyroid. Arch Pathol Lab Med June 2001, 125:482–483.
- Tovi F, Mares AJ: The abbarent cervical thymus: embryology, pathology, and clinical implications. Am J Surg 1978, 136:631–637.PubMedView Article
- Hayashi S, Hamanaka Y, Sueda T, Yonihara S, Matsuura Y: Thymic metastasis from prostatic carcinoma: a case report. Surg Today 1993, 23:632–634.PubMedView Article
- Phillips CJ: Case report: metastatic malignant testicular teratoma of the thymus. Br J Radiol 1994, 67:203–204.PubMedView Article
- Nam MS, Chu YC, Choe WS, Kim SJ, et al.: Metastatic follicular thyroid carcinoma of thymus in a 35 year old women. Yonsei Med J 2002, 43:665–669.PubMed
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.