The pathogenesis of angiolipomas is unknown. They may result from abnormal development of the primitive, pluripotential mesenchymal cells from which adipose tissue and vascular endothelium arise or may be hamartomatous in nature . Other proposed etiologic possibilities include fatty degeneration of a central hemangioma or vascular proliferation of a congenital lipoma [6, 7].
On physical examination, angiolipomas usually present as tender, subcutaneous nodules of white adipose tissue. They are rarely associated with overlying skin discoloration. Angiolipoma is a rare variant of lipoma and they occur in the extremities in the spinal axis and in the neck and head [4–6, 8, 9]. Only three cases occurring at the foot have been previously described [4, 8, 9]. The most common symptom is a constant, dull pain with associated neuropathies secondary to vascular engorgement and edema, which can lead to compression of the adjacent neural tissue [10, 11]. Our patient had a tender, semi-mobile nodule at the plantar surface of the forefoot.
The diagnosis of angiolipoma can be aided by computed tomography (CT) or magnetic resonance imaging (MRI). On contrast-enhanced studies, angiolipomas demonstrate a marked enhancement as a result of their intense vascularity. Noncontrast studies demonstrate the homogenous low attenuation of a typical lipoma . In our patient, MRI detected a well-defined lesion with no infiltration into adjacent tissues. In our case, also, the presence of many thick-walled vessels and the degenerative lesions of the adipose tissue to our opinion can be explained on the bases of the "age", (long duration), of the neoplasm and its location, which caused mechanical pressure. Beside this estimation the mast cells, which observed in high numbers, play a role to the consistency of the intermediate stroma.
The main challenge of these otherwise benign tumors is first to establish a correct diagnosis. They belong to a wider spectrum ranging from benign pure lipomas, composed of adipose tissue, to benign pure angiomas, composed of vascular tissue. They probably lie in the middle of this spectrum and according to the relative percentages of adipose and vascular tissues, can be divided as lipomatous or angiomatous types [8, 9].
Although a presumptive diagnosis is typically made clinically, these tumors with atypical clinical features may require radiological consultation. Difficulty arises when radiographic features are not typical of lipoma. Radiological evaluation is diagnostic in up to 71% of cases. These lesions are identical to subcutaneous fat on computed CT and MRI images . MRI could be a useful tool to diagnose local areas of infiltration .
Histopathologically angiolipomas are characterized by mature adipose tissue containing copious vascular elements that vary from sinusoids, thin-walled vessels or thick-walled vessels with proliferation of the smooth muscle layer . Mitotic figures are infrequent and malignant changes have not been identified . They vary in color from whitish-yellow to a grayish-purple. Immunohistochemistry, if histology is not helpful, can be of some help in the final diagnosis.
Based on studies by Dionne  and Lin , angiolipomas are subdivided into two histological types: infiltrating and noninfiltrating. Infiltrating angiolipomas are characteristically not encapsulated, and they infiltrate into surrounding tissue. Their clinical behavior is similar to that of hemangiomas. Infiltrating angiolipomas are usually diagnosed in older patients. The vast majority occur in the lower extremities or in the paraspinal region, which can lead to muscular pain and neural deficits [6, 11, 15]. In their study of 459 lipomas, Lin and Lin  found that 25 (5.4%) met the criteria for angiolipoma. Two of the 25 angiolipomas were microscopically unencapsulated and showed some degree of infiltration into adjacent tissues. Noninfiltrating, or circumscribed, angiolipomas are encapsulated lesions limited to the subcutaneous compartment. Their size almost never exceeds 4 cm. These lesions are more common in young people, and they are equally distributed between the sexes.
Although angiolipomas are benign lesions sometimes they can be more aggressive and invade the contiguous bone and adjacent soft tissues [16, 17]. Contrary to lipomas and angiomas, the possibility to infiltrate bone and bone marrow renders them more susceptible to local recurrence . In these cases, only bone amputation or postoperative radiotherapy can provide a definitive cure [8, 9].
Differentiation of angiolipomas from liposarcomas based on imaging features is not possible some times necessitating surgical resection for definitive histological diagnosis . The differentiation is based on cellular atypia, mitotic figures, and cellular pleomorphism, which is seen with malignant lesions. In addition, the lipocytes of liposarcoma resemble embryonic adipose tissue and the vasculature of liposarcoma contains only capillaries, and the veins are seen within the angiolipoma. Differentiation of angiolipomas from others lipoma variants (lipomatosis, myolipoma, chondroid lipoma, hibernoma, spindle cell lipoma, atypical lipoma, pleomorphic lipoma, lipoblastoma) and understanding the spectrum of appearances of the various benign musculoskeletal lipomatous lesions improves radiological assessment and is vital for optimal patient management. Lipomatosis represents a diffuse overgrowth of mature fat affecting subcutaneous tissue, muscle or nerve, and imaging is needed to evaluate lesion extent. Lipoblastoma is a tumor of immature fat occurring in young children, and imaging features may reveal a mixture of fat and nonadipose tissue. Angiolipoma, myolipoma, and chondroid lipoma are rare lipomatous lesions that are infrequently imaged. Spindle cell and pleomorphic lipoma appear as a subcutaneous lipomatous mass in the posterior neck or shoulder, with frequent nonadipose components. Hibernoma appears as a lipomatous mass with serpentine vascular elements.
Benign lipomatous lesions affecting bone, joint, or tendon sheath include intraosseous lipoma, parosteal lipoma, liposclerosing myxofibrous tumor, discrete lipoma of joint or tendon sheath, and lipoma arborescens. Intraosseous and parosteal lipoma have a pathognomonic CT or MRI appearance, with fat in the marrow space or on the bone surface, respectively. Liposclerosing myxofibrous tumor is a rare intermixed histological lesion commonly located in the medullary canal of the intertrochanteric femur. Benign lipomatous lesions may occur focally in a joint or tendon sheath or with diffuse villonodular proliferation in the synovium (lipoma arborescens) and are diagnosed based on location and identification of fat.
The treatment of both infiltrating and noninfiltrating angiolipomas is total surgical excision. The infiltrating type of lesion is associated with more treatment difficulties. These lesions have been reported to recur after surgical excision in 35 to 50% of cases . Wide local excision with free margins is the preferred surgical procedure; in cases of inadequate excision, radiation therapy is necessary [6, 11]. For noninfiltrating angiolipomas, simple excision is curative because these lesions have no tendency to recur following surgical removal. In our patient marginal surgical excision using a longitudinal incision was performed and after one-year of follow-up the patient showed no signs of recurrence.