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  1. To avoid the inconvenience of triangulation among various rigid operating instruments in mediastinoscopy-assisted esophagectomy, we invented a new technique: used a flexible endoscope to mobilize thoracic esop...

    Authors: Chun-Li Wu, Bo Dong, Bin Wu, Shi-Hao Li and Yu Qi

    Citation: World Journal of Surgical Oncology 2021 19:234

    Content type: Technical innovations

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  2. Colon neuroendocrine neoplasms (NENs) have one of the poorest median overall survival (OS) rates among all NENs. The American Joint Committee on Cancer (AJCC) tumor–node–metastasis (TNM) staging system—current...

    Authors: Ruitong Xu, Bingrong Zhou, Ping Hu, Bingyan Xue, Danyang Gu, Xiaolin Li and Qiyun Tang

    Citation: World Journal of Surgical Oncology 2021 19:233

    Content type: Research

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  3. The clinical efficacy and safety of maintenance therapy (MT) for patients with advanced non-small cell lung cancer (NSCLC) have not been determined in the real word. This retrospective study of real-world data...

    Authors: Xiangwei Xu, Ruya Li, Peizhen Zhu, Penghai Zhang, Jun Chen, Yongsheng Lin and Yinqiao Chen

    Citation: World Journal of Surgical Oncology 2021 19:231

    Content type: Research

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  4. Digestive tract reconstruction in totally laparoscopic total gastrectomy can be divided into two types: instrument anastomosis and hand-sewn anastomosis. This study explored the feasibility and safety of hand-...

    Authors: Zeshen Wang, Yuzhe Wei, Xirui Liu, Zhenglong Li, Guanyu Zhu, Yanfeng Li and Kuan Wang

    Citation: World Journal of Surgical Oncology 2021 19:229

    Content type: Research

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  5. The purposes of this study were to assess the correlation between the plasma level of Hsp90α and the clinicopathological characteristics of patients with liver cancer and compare the diagnostic efficacy of Hsp...

    Authors: Yueting Han, Youqin Zhang, Lin Cui, Ze Li, Honglei Feng, Ying Zhang, Da Sun and Li Ren

    Citation: World Journal of Surgical Oncology 2021 19:228

    Content type: Research

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  6. Immunoinflammatory and nutritional markers, such as the peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and Onodera’s prognostic nutritional index (OPNI), have gained ...

    Authors: Feng Wang, Tingting Tao, Heng Yu, Yingying Xu, Zhi Yang, Xuefeng Xia, Meng Wang, Liang Zong and Wenxian Guan

    Citation: World Journal of Surgical Oncology 2021 19:227

    Content type: Research

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  7. Intrahepatic cholangiocarcinoma is an aggressive liver carcinoma with increasing incidence and mortality. A good auxiliary prognostic prediction tool is desperately needed for the development of treatment stra...

    Authors: Youyin Tang, Tao Zhang, Xianghong Zhou, Yunuo Zhao, Hanyue Xu, Yichun Liu, Hang Wang, Zheyu Chen and Xuelei Ma

    Citation: World Journal of Surgical Oncology 2021 19:45

    Content type: Research

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  8. Extramedullary leukemia, also known as myeloid sarcoma, is a rare form of acute myeloid leukemia and often accompanies bone marrow involvement. Myeloid infiltration of the thyroid gland is extremely rare. Here...

    Authors: Mehmet Sözen, Çiğdem Vural, Alev Selek, Umay Kiraz, Zeynep Cantürk, Berrin Çetinarslan, Emre Gezer and Damla Köksalan

    Citation: World Journal of Surgical Oncology 2021 19:225

    Content type: Case report

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  9. 5-Methylcytosine (m5C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in developing human cancers are poorly understood, including the effects of mutant m5C regulators and ...

    Authors: Yuting He, Xiao Yu, Menggang Zhang and Wenzhi Guo

    Citation: World Journal of Surgical Oncology 2021 19:224

    Content type: Research

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  10. While large-scale genomic analyses symbolize a precious attempt to decipher the molecular foundation of uterine leiomyosarcoma (ULMS), bioinformatics results associated with the occurrence of ULMS based totall...

    Authors: Xiaoqing Shen, Zhujuan Yang, Songwei Feng and Yi Li

    Citation: World Journal of Surgical Oncology 2021 19:223

    Content type: Research

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  11. Surgical resection (SR) has been selectively applied in hepatocellular carcinoma (HCC) presenting with minor gross vascular invasion (mGVI) which is defined when tumor invasion is confined to second-order port...

    Authors: Byungje Bae, Sung Kyu Song, Eunyoung Choi, Chul-Woon Chung and Yongkeun Park

    Citation: World Journal of Surgical Oncology 2021 19:222

    Content type: Research

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  12. The aim of this study is to determine the incidence trends of urothelial cancer of the bladder (UCB) and to develop a nomogram for predicting the cancer-specific survival (CSS) of postsurgery UCB at a populati...

    Authors: Hairong He, Tianjie Liu, Didi Han, Chengzhuo Li, Fengshuo Xu, Jun Lyu and Ye Gao

    Citation: World Journal of Surgical Oncology 2021 19:221

    Content type: Research

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  13. The aim of this study was to analyze prognostic factors for ovarian metastases (OM) in colorectal cancer (CRC) using data from a Chinese center. In addition, the study aimed at developing a new clinical scorin...

    Authors: Chao Chen, Da Wang, Xiaoxu Ge, Jian Wang, Yuhuai Huang, Tianyi Ling, Tian Jin, Jinhua Yang, Fengping Wang, Weihong Wu and Lifeng Sun

    Citation: World Journal of Surgical Oncology 2021 19:220

    Content type: Research

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  14. Gastric cancer (GC) commonly relates to dismal prognosis and lacks efficient biomarkers. This study aimed to establish an antioxidant-related gene signature and a comprehensive nomogram to explore novel biomar...

    Authors: Jianhua Wu, Xuan Wang, Nan Wang, Li Ma, Xin Xie, Hao Zhang, Huafeng Kang and Zhangjian Zhou

    Citation: World Journal of Surgical Oncology 2021 19:219

    Content type: Research

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  15. Systemic inflammation and nutritional status are associated with tumor development and progression. This study investigated the prognostic value of fibrinogen/albumin ratio index (FARI) in predicting recurrenc...

    Authors: Hu Liu, Guoteng Qiu, Fengjuan Hu and Hong Wu

    Citation: World Journal of Surgical Oncology 2021 19:218

    Content type: Research

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  16. Despite the established oncological benefits of neoadjuvant chemotherapy for esophageal squamous cell cancer, not all cases demonstrate benefit. Hence, predicting the response to chemotherapy before treatment ...

    Authors: Seiichi Nakaya, Ryo Ogawa, Shunsuke Hayakawa, Shiro Fujihata, Tomotaka Okubo, Hiroyuki Sagawa, Tatsuya Tanaka, Hiroki Takahashi, Yoichi Matsuo and Shuji Takiguchi

    Citation: World Journal of Surgical Oncology 2021 19:217

    Content type: Research

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  17. Gastric cancer (GC) represents a major malignancy and is the third deathliest cancer globally. Several lines of evidence indicate that the epithelial-mesenchymal transition (EMT) has a critical function in the...

    Authors: Wanting Song, Yi Bai, Jialin Zhu, Fanxin Zeng, Chunmeng Yang, Beibei Hu, Mingjun Sun, Chenyan Li, Shiqiao Peng, Moye Chen and Xuren Sun

    Citation: World Journal of Surgical Oncology 2021 19:216

    Content type: Research

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  18. The programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) have shown positive efficacy in several solid cancers due to their targeted antitumour effects. However, the frequency and clinical implication v...

    Authors: Juan He, Min Yi, Lingfeng Tan, Jianghua Huang and Lin Huang

    Citation: World Journal of Surgical Oncology 2021 19:215

    Content type: Research

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  19. The radiation-induced lung injury (RILI) in patients with advanced non-small cell lung cancer (NSCLS) is very common in clinical settings; we aimed to evaluate the risk factors of RILI in NSCLS patients, to pr...

    Authors: Sha Sha, Jigang Dong, Maoyu Wang, Ziyu Chen and Peng Gao

    Citation: World Journal of Surgical Oncology 2021 19:214

    Content type: Research

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  20. Response evaluation following neoadjuvant chemotherapy (NAC) in gastric cancer is debated. The aim of this study was to investigate the value of UICC-downstaging as mode of response evaluation following a MAGIC-s...

    Authors: Alina Desiree Sandø, Reidun Fougner, Jon Erik Grønbech and Erling Audun Bringeland

    Citation: World Journal of Surgical Oncology 2021 19:212

    Content type: Research

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  21. The aim of this study was to evaluate the predictive factors of central lymph node metastasis (CLNM) and BRAFV600E mutation in Chinese patients with papillary thyroid carcinoma (PTC).

    Authors: Sheng Li Zhou, Yan Ping Guo, Lei Zhang, Tao Deng, Zi Guang Xu, Chao Ding, Wen Cong Sun, Yue Wu Zhao and Ling Fei Kong

    Citation: World Journal of Surgical Oncology 2021 19:211

    Content type: Research

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  22. This meta-analysis was implemented to evaluate the association between hypoxia-inducible factor-1α (HIF-1α) C1772T/G1790A polymorphisms and susceptibility to head and neck cancer (HNC).

    Authors: Ting Wu, Zhong-ti Zhang, Lin Li, Ru-yue Liu and Bao-ting Bei

    Citation: World Journal of Surgical Oncology 2021 19:210

    Content type: Review

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  23. This study aimed to evaluate the clinical outcomes for patients with stage IB2/IIA2 cervical squamous cell carcinoma treated with neoadjuvant chemotherapy combined with radical surgery.

    Authors: Huang Jing, Wu Xiuhong, Yu Ying, Liao Zhenrong, Cheng Xiyun, Luo Deping, Shen Changmei, Wang Qi, Peng Tao and Pan Yiyun

    Citation: World Journal of Surgical Oncology 2021 19:209

    Content type: Research

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  24. An abrupt increase of thyroid cancer has been witnessed paralleling the supplemented iodine intake in formerly iodine-deficient countries. And increased iodine intake has been linked to the rising incidence ra...

    Authors: Ziyang Zeng, Kang Li, Xianze Wang, Siwen Ouyang, Zimu Zhang, Zhen Liu, Juan Sun, Xin Ye, Weiming Kang and Jianchun Yu

    Citation: World Journal of Surgical Oncology 2021 19:208

    Content type: Research

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  25. Mounting evidence in the cancer literature suggests that microRNAs (miRNAs) influence the progression of human cancer cells by targeting protein-coding genes. How insulin-like growth factor 1(IGF1) and miR-186...

    Authors: Xiurong Lu, Xiao Song, Xiaohui Hao, Xiaoyu Liu, Xianyu Zhang, Na Yuan, Huan Ma and Zhilin Zhang

    Citation: World Journal of Surgical Oncology 2021 19:207

    Content type: Research

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  26. The oncological outcomes of laparoscopic gastrectomy (LG) and open gastrectomy (OG) following neoadjuvant chemotherapy have been investigated in a few studies. Our purpose was to evaluate the oncological outco...

    Authors: Islam Khaled, Pablo Priego, Hany Soliman, Mohammed Faisal and Ihab Saad Ahmed

    Citation: World Journal of Surgical Oncology 2021 19:206

    Content type: Research

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  27. To assess the value of adjuvant radiotherapy for treatment of gastric adenocarcinoma and to investigate subgroups of patients suitable for adjuvant radiotherapy.

    Authors: Peng Wang, Haihua Zhou, Gaohua Han, Qingtao Ni, Shengbin Dai, Junxing Huang, Chunlei Dai and Lei Yu

    Citation: World Journal of Surgical Oncology 2021 19:205

    Content type: Research

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  28. Postoperative infectious complications (ICs) after surgery for colorectal cancer (CRC) increase in-hospital deaths and decrease long-term survival. However, the methodology for IC preoperative and intraoperati...

    Authors: Jing Wen, Tao Pan, Yun-chuan Yuan, Qiu-shi Huang and Jian Shen

    Citation: World Journal of Surgical Oncology 2021 19:204

    Content type: Research

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  29. Radical cystectomy (RC) is the standard treatment for bladder cancer, but the safety and efficacy of this treatment for elderly people need to be considered. We compare perioperative data and survival outcomes...

    Authors: Shangxun Xie, Zihan Zhao, Baofu Feng, Shiwei Zhang, Gutian Zhang, Xiaogong Li, Hongqian Guo and Rong Yang

    Citation: World Journal of Surgical Oncology 2021 19:202

    Content type: Research

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  30. The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host–tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in ...

    Authors: Masaaki Nishi, Mistuo Shimada, Takuya Tokunaga, Jun Higashijima, Kozo Yoshikawa, Hideya Kashihara, Chie Takasu, Daichi Ishikawa, Yuma Wada, Shohei Eto and Toshiaki Yoshimoto

    Citation: World Journal of Surgical Oncology 2021 19:201

    Content type: Research

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  31. The prognosis of patients with colorectal cancer and peritoneal metastasis (CRC-PM) after incomplete cytoreductive surgery (CRS) or palliative surgery is poor. Novel and effective therapies are urgently needed...

    Authors: Tuanhe Sun, Kang Li, Gang Xu, Kun Zhu, Qiong Wang, Chengxue Dang and Dawei Yuan

    Citation: World Journal of Surgical Oncology 2021 19:200

    Content type: Research

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  32. Dysregulation of long non-coding RNAs has been implied to connect with cancer progression. This research was to decipher the mechanism of long non-coding RNA SDCBP2-AS1 in ovarian cancer (OC) through regulatio...

    Authors: Xiu Liu, Chanyuan Liu, Aijun Zhang, Qi Wang, Jiao Ge, Qunying Li and Jinlei Xiao

    Citation: World Journal of Surgical Oncology 2021 19:199

    Content type: Research

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  33. This study was designed to evaluate the safety and effectiveness of a two-hand technique combining harmonic scalpel (HS) and laparoscopic Peng’s multifunction operative dissector (LPMOD) in patients who underw...

    Authors: Jingwei Cai, Guixing Jiang, Yuelong Liang, Yangyang Xie, Junhao Zheng and Xiao Liang

    Citation: World Journal of Surgical Oncology 2021 19:198

    Content type: Research

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  34. Programs of Enhanced Recovery After Surgery reduces morbidity and shorten recovery in patients undergoing colorectal resections for cancer. Patients presenting with more advanced disease such as T4 cancers are...

    Authors: Vittoria Bellato, Yongbo An, Daniele Cerbo, Michela Campanelli, Marzia Franceschilli, Krishn Khanna, Bruno Sensi, Leandro Siragusa, Piero Rossi and Giuseppe S. Sica

    Citation: World Journal of Surgical Oncology 2021 19:196

    Content type: Research

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  35. To describe the techniques and outcomes of complete transperitoneal laparoscopic nephroureterectomy (CTLNU) for upper urinary tract urothelial carcinoma (UTUC) in a single position.

    Authors: Chengwu Xiao, Yang Wang, Meimian Hua, Wei Zhang, Guanyu Ren, Bin Yang and Qing Yang

    Citation: World Journal of Surgical Oncology 2021 19:195

    Content type: Research

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  36. Placement of a self-expanding metal stent (SEMS) in patients presenting with an acute colorectal obstruction (ACO) may obviate emergency surgery (ES), potentially effectively palliating incurable tumors, actin...

    Authors: Fei-hu Yan, Yao Zhang, Cheng-ling Bian, Xiao-shuang Liu, Bing-chen Chen, Zhen Wang, Hao Wang, E. Ji-fu and En-da Yu

    Citation: World Journal of Surgical Oncology 2021 19:194

    Content type: Research

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  37. Desmoplastic small round cell tumor (DSRCT) is a highly malignant sarcoma that occurs in the abdominopelvic cavities of adolescents. The accurate diagnosis of DSRCT is challenging owing to limited literatures....

    Authors: Ling-Ling Wang, Zhong-He Ji, Ying Gao, Hong Chang, Ping-Ping Sun and Yan Li

    Citation: World Journal of Surgical Oncology 2021 19:193

    Content type: Research

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  38. Clinical evidence has proved that enhanced recovery after surgery (ERAS) can improve short-term clinical outcomes after various types of surgeries, but the long-term benefits have not yet been examined, especi...

    Authors: Qianyun Pang, Liping Duan, Yan Jiang and Hongliang Liu

    Citation: World Journal of Surgical Oncology 2021 19:191

    Content type: Review

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  39. The purpose of this study was to evaluate the effects of cytoreductive nephrectomy (CN) and metastasectomies on the survival of patients with synchronous metastatic renal cell cancer (mRCC) using real-life, po...

    Authors: Lauri Laru, Hanna Ronkainen, Pasi Ohtonen and Markku H. Vaarala

    Citation: World Journal of Surgical Oncology 2021 19:190

    Content type: Research

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  40. Understanding the vascular anatomy is critical for performing central vascular ligation (CVL) in right hemicolectomy with complete mesocolic excision (CME). This study aimed to investigate the predictive value...

    Authors: Hui Yu, Yong Zhuang, Jinliang Jian and Chunkang Yang

    Citation: World Journal of Surgical Oncology 2021 19:189

    Content type: Research

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  41. Postoperative symptomatic anastomotic leakage (AL) is a serious complication after low anterior resection (LAR) for rectal cancer. AL can potentially affect short-term patient outcomes and long-term prognosis....

    Authors: Xinyu Qi, Maoxing Liu, Kai Xu, Pin Gao, Fei Tan, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui and Xiangqian Su

    Citation: World Journal of Surgical Oncology 2021 19:187

    Content type: Research

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