Articles

Case report: late perianal mucinous adenocarcinoma after Crohn's disease proctectomy: an oncological rarity

As in ulcerative colitis, there is an increased incidence of colorectal carcinoma in Crohn's disease. While carcinoma formation originating from ano-rectal fistulas is generally considered as a rare event ther...

Authors: Michael Keese, Walter Back, Dietmar Dinter, Rainer Gladisch, Andreas Joos and Pablo Palma

Sentinel node biopsy as an adjunct to limb salvage surgery for epithelioid sarcoma of the hand

Epithelioid sarcomas of the hand are rare, high-grade tumors with a propensity for regional lymphatic spread approaching 40%.

Authors: Alex Seal, Raymond Tse, Bret Wehrli, Alex Hammond and Claire LF Temple

Transhiatal and transthoracic resection in adenocarcinoma of the esophagus: Does the operative approach have an influence on the long-term prognosis?

The goal of the present analysis was to investigate the long-term prognosis for adenocarcinoma of the esophagus treated with either the transhiatal (TH) or the transthoracic (TT) operative approach.

Authors: Ines Gockel, Sina Heckhoff, Claudia M Messow, Werner Kneist and Theodor Junginger

Huge parathyroid carcinoma: Clinical considerations and literature review

Parathyroid carcinoma is a rare malignancy, with an incidence of 0.5 to 4% of all cases of primary hyperparathyroidism. Surgery is the only curative treatment.

Authors: Maria Grazia Chiofalo, Francesco Scognamiglio, Simona Losito, Secondo Lastoria, Ugo Marone and Luciano Pezzullo

E-cadherin and β-catenin expression in early stage cervical carcinoma: a tissue microarray study of 147 cases

The disruption of intercellular adhesions is an important component of the acquisition of invasive properties in epithelial malignancies. Alterations in the cell-cell adhesion complex, E-Cadherin/β-Catenin, ha...

Authors: Oluwole Fadare, Harini Reddy, Jun Wang, Denise Hileeto, Peter E Schwartz and Wenxin Zheng

Morbidity and mortality after esophagectomy for esophageal carcinoma: A risk analysis

The study was aimed to identify pre- and intraoperative risk factors that potentially influence morbidity and mortality after esophagectomy for esophageal carcinoma with particular emphasis on the predominant ...

Authors: Ines Gockel, Christoph Exner and Theodor Junginger

Goblet cell carcinoid of the appendix

Goblet cell carcinoid (GCC) of the appendix is a rare neoplasm that share histological features of both adenocarcinoma and carcinoid tumor. While its malignant potential remains unclear, GCC's are more aggress...

Authors: Payam S Pahlavan and Rani Kanthan

Secretory carcinoma of the breast containing the ETV6-NTRK3 fusion gene in a male: case report and review of the literature

Secretory carcinoma (SC) of the breast is a rare and indolent tumor. Although originally described in children, it is now known to occur in adults of both sexes. Recently, the tumor was associated with the ETV...

Authors: C Arce, D Cortes-Padilla, DG Huntsman, MA Miller, A Dueñnas-Gonzalez, A Alvarado, V Pérez, D Gallardo-Rincón and F Lara-Medina

Long term remission of metastatic placental site trophoblastic tumor (PSTT): Case report and review of literature

Placental site trophoblastic tumor (PSTT) is a rare and unique form of gestational trophoblastic disease (GTD). This tumor represents a neoplastic transformation of intermediate trophoblastic cells. We documen...

Authors: Nadereh Behtash, Fatemeh Ghaemmaghami and Malihe Hasanzadeh

Surgical management of abdominal and retroperitoneal Castleman's disease

Abdominal and retroperitoneal Castleman's disease could present either as a localized disease or as a systemic disease. Castleman's disease is a lymphoid hyperplasia related to human Herpes virus type 8, which...

Authors: Pascal Bucher, Gilles Chassot, Guillaume Zufferey, Frederic Ris, Olivier Huber and Philippe Morel

Long-term survival after an aggressive surgical resection and chemotherapy for stage IV pulmonary giant cell carcinoma

Pulmonary giant cell carcinoma is one of the rare histological subtypes with pleomorphic, sarcomatoid or sarcomatous elements. The prognosis of patients with this tumor tends to be poor, because surgery, irrad...

Authors: Fumihiro Shoji, Riichiroh Maruyama, Tatsuro Okamoto, Jiro Ikeda, Tomomi Nakamura, Hiroshi Wataya and Yukito Ichinose

Fallacies of preoperative lymphoscintigraphy in detecting sentinel node in breast cancer

Preoperative lymphoscintigraphy is one of the three methods of evaluating sentinel nodes in patients with breast cancer; however, it has been reported to have a high false negative rate.

Authors: Manoj Pandey, Surya VS Deo and R Maharajan

Inflammatory fibroid polyp of the oesophagus

Inflammatory fibroid polyp of the oesophagus is an uncommon lesion and very rarely it grows rapidly.

Authors: Shashi Kanth Godey and Robert T Diggory

Ventricular metastasis resulting in disseminated intravascular coagulation

Disseminated Intravascular Coagulation (DIC) complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC) has rarely been associated with ...

Authors: Thomas John and Ian D Davis

Gastric extremely well differentiated adenocarcinoma of gastric phenotype: as a gastric counterpart of adenoma malignum of the uterine cervix

Most of gastric adenocarcinoma can be simply diagnosed by microscopic examination of biopsy specimen. Rarely the structural and cellular atypia of tumor cells is too insignificant to discriminate from benign f...

Authors: Won Ae Lee

Viral hepatitis and hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The incidence of HCC varies considerably with the geographic area because of differences in the major causative factors. ...

Authors: Peter P Michielsen, Sven M Francque and Jurgen L van Dongen

The immunogenicity of colorectal cancers with high-degree microsatellite instability

High-degree microsatellite instability (MSI-H) is a feature of approximately 15% of sporadic colorectal cancers. Patients with MSI-H cancers have been reported to have a better prognosis than those with non-MS...

Authors: Ayan Banerjea, Stephen A Bustin and Sina Dorudi

Erratum to: Perivascular epithelioid cell tumor (PEComa) of the uterine cervix associated with intraabdominal "PEComatosis": A clinicopathological study with comparative genomic hybridization analysis

Authors: Oluwole Fadare, Vinita Parkash, Yesim Yilmaz, M Rajan Mariappan, Linglei Ma, Denise Hileeto, Mazin B Qumsiyeh and Pei Hui

Inflammatory myofibroblastic tumour of the gallbladder

Inflammatory myofibroblastic tumour (IMT) is a benign, nonmetastasizing proliferation of myofibroblasts with a potential for local infiltration, recurrence and persistent local growth.

Authors: Kasim A Behranwala, Peter Straker, Andrew Wan, Cyril Fisher and Jeremy N Thompson

Management of leiomyosarcomas of the spermatic cord: the role of reconstructive surgery

Leiomyosarcomas (LMS) of the spermatic cord are extremely rare. Radical inguinal orchiectomy and high ligation of the cord is the standard primary surgical procedure. The extent of surrounding soft tissue exci...

Authors: Stuart Enoch, Simon M Wharton and Douglas S Murray

Neck dissection: an operation in evolution

Authors: Ashok R Shaha

Neck dissections: radical to conservative

Neck dissection is an important surgical procedure for the management of metastatic nodal disease in the neck. The gold standard of neck nodal management has been the radical neck dissection. Any modification ...

Authors: K Harish

Feasibility of chemosensitivity testing in soft tissue sarcomas

Soft tissue sarcomas comprise less than 1% of all solid malignancies. The presentation and behavior of these tumors differs depending on location and histological characteristics. Standard therapy consists of ...

Authors: Marcus Lehnhardt, Thomas Muehlberger, Cornelius Kuhnen, Daniel Brett, Hans U Steinau, Hamid Joneidi Jafari, Lars Steinstraesser, Oliver Müller and Heinz H Homann

Intrapulmonal dislocation of a totally implantable venous access device

Totally implantable venous access devices are widely used for infusion of chemotherapy or parenteral nutrition. Device associated complications include technical operative problems, infections, paravasal infus...

Authors: Thilo Hackert, Christin Tjaden, Angelika Kraft, Bernd Sido, Hendrik Dienemann and Markus W Buchler

Increase in number of circulating disseminated epithelial cells after surgery for non-small cell lung cancer monitored by MAINTRAC^® is a predictor for relapse: A preliminary report

Lung cancer still remains one of the most commonly occurring solid tumors and even in stage Ia, surgery fails in 30% of patients who develop distant metastases. It is hypothesized that these must have develope...

Authors: Axel Rolle, Rainer Günzel, Ulrich Pachmann, Babette Willen, Klaus Höffken and Katharina Pachmann

Optimising surgical management of elderly cancer patients

Elderly population is on rise. It is an ethical dilemma how aggressive one should be when it comes to treat cancer in elderly. Presumed fear of increased postoperative morbidity and mortality has resulted in d...

Authors: Hodigere Sripathy Jois Ramesh, Daniel Pope, Roberto Gennari and Riccardo A Audisio

Angiogenesis in male breast cancer

Male breast cancer is a rare but aggressive and devastating disease. This disease presents at a later stage and in a more advanced fashion than its female counterpart. The immunophenotype also appears to be di...

Authors: Evan M Frangou, Joshua Lawson and Rani Kanthan

Locally advanced duodenal gangliocytic paraganglioma treated with adjuvant radiation therapy: case report and review of the literature

Gangliocytic paraganglioma are rare neoplasms that predominantly arise in periampulary region. Though considered benign the disease can spread to regional lymphatics.

Authors: Adrian Wong, Alexander R Miller, John Metter and Charles R Thomas Jr

A giant subcutaneous leiomyosarcoma arising in the inguinal region

Subcutaneous leiomyosarcoma is a rare condition that accounts for 1% to 2% of all superficial soft tissue malignancies. Approximately 10% of cases arise in the trunk, although the extremities are the most comm...

Authors: Kazuhito Yajima, Yoshio Shirai, Nobuhiro Fujita, Daisuke Sato, Hajime Umezu and Katsuyoshi Hatakeyama

Umbilical metastases: current viewpoint

Umbilical metastases from a malignant neoplasm, also termed Sister Mary Joseph's nodule, are not commonly reported in the English literature, and they have usually been considered as a sign of a poor prognosis...

Authors: Raimondo Gabriele, Marco Conte, Federico Egidi and Mario Borghese

A case-control study to evaluate urinary tract complications in radical hysterectomy

This study has evaluated urinary tract injuries and dysfunction after Radical Hysterectomy (RH) performed in patients with cervical cancer and has compared the cystometric parameters and urinary complications ...

Authors: Nadereh Behtash, Fatemeh Ghaemmaghami, Haleh Ayatollahi, Hediyeh Khaledi and Parviz Hanjani

Spontaneous rupture of giant gastric stromal tumor into gastric lumen

Gastrointestinal stromal tumors (GIST) constitute a large majority of mesenchymal tumors of the gastrointestinal (GI) tract, which express the c-kit proto-oncogene protein, a cell membrane receptor with tyrosi...

Authors: Rajiv M Mehta, Vayoth O Sudheer, Anil K John, Raghavan R Nandakumar, Puneet S Dhar, Surendran Sudhindran and Vallath Balakrishnan

Diagnosis and treatment of carotid body paraganglioma: 21 years of experience at a clinical center of Serbia

The carotid body paraganglioma (chemodectoma) is a relatively rare neoplasm of obscure origin. These are usually benign and commonly present as asymptomatic cervical mass.

Authors: Lazar B Davidovic, Vojko B Djukic, Dragan M Vasic, Radomir P Sindjelic and Stevo N Duvnjak

Long-term survival from gastrocolic fistula secondary to adenocarcinoma of the transverse colon

Gastrocolic fistula is a rare presentation of both benign and malignant diseases of the gastrointestinal tract. Malignant gastrocolic fistula is most commonly associated with adenocarcinoma of the transverse c...

Authors: Matthew J Forshaw, Jamasp K Dastur, Kothandaraman Murali and Michael C Parker

Age dependent association of endometrial polyps with increased risk of cancer involvement

Endometrial polyps (EMPs) are commonly encountered in routine surgical pathology practice, but opinions differ on whether they are intrinsically a marker for concurrent or subsequent malignancy. The objectives...

Authors: Denise Hileeto, Oluwole Fadare, Maritza Martel and Wenxin Zheng

A novel surgical procedure for bridging of massive bone defects

Bony defects arising from tumor resection or debridement after infection, non-union or trauma present a challenging problem to orthopedic surgeons, as well as patients due to compliance issues. Current treatme...

Authors: Ulf R Knothe and Dempsey S Springfield

Resection of small plexiform neurofibromas in neurofibromatosis type 1 children

Plexiform neurofibromas (PNF) are benign tumors of the peripheral nerve which mostly develop in patients with neurofibromatosis type 1 (NF1). Surgical interventions are usually not applied to children with sma...

Authors: Reinhard E Friedrich, Rainer Schmelzle, Melanie Hartmann, Carsten Fünsterer and Victor-F Mautner

Prognostic significance of metallothionein expression in renal cell carcinoma

Metallothionein (MT) protein expression deficiency has been implicated in carcinogenesis while MT over expression in tumors is indicative of tumor resistance to anti-cancer treatment. The purpose of the study ...

Authors: Dionisios Mitropoulos, Aspasia Kyroudi-Voulgari, Stamatis Theocharis, Efraim Serafetinides, Epaminondas Moraitis, Anastasios Zervas and Christos Kittas

Sister Joseph's nodule in a liver transplant recipient: Case report and mini-review of literature

Umbilical metastasis is one of the main characteristic signs of extensive neoplastic disease and is universally referred to as Sister Mary Joseph's nodule.

Authors: Fabrizio Panaro, Enzo Andorno, Stefano Di Domenico, Nicola Morelli, Giuliano Bottino, Rosalia Mondello, Marco Miggino, Tomasz M Jarzembowski, Ferruccio Ravazzoni, Marco Casaccia and Umberto Valente

An unusual presentation of a malignant jejunal tumor and a different management strategy

Malignant small bowel tumors are very rare and leiomyosarcoma accounts for less than 15% of the cases. Management of these tumors is challenging in view of nonspecific symptoms, unusual presentation and high i...

Authors: Atul Samaiya, SV Suryanarayana Deo, Sanjay Thulkar, Sidhartha Hazarika, Sunil Kumar, Dillip K Parida and Nootan K Shukla

Expression of vascular endothelial growth factor (VEGF)-C in preoperative biopsy specimens and metastatic foci of regional lymph nodes in submucosal gastric carcinoma

Vascular endothelial growth factor (VEGF)-C is implicated in lymphangiogenesis, however the exact role of VEGF-C in promoting lymphatic spread of cancer cells remains largely unknown.

Authors: Makoto Ishikawa, Joji Kitayama, Shinsuke Kazama and Hirokazu Nagawa

Core biopsy as a tool in planning the management of invasive breast cancer

Core biopsy is a method of choice for the triple assessment of breast disease as it can reliably distinguish between benign and malignant tumours, between in-situ and invasive cancers and can be useful to assess ...

Authors: Amar Deshpande, Trivikram Garud and Simon D Holt

The prognosis of women with stage IB1-IIB node-positive cervical carcinoma after radical surgery

Pelvic lymph nodes metastasis is an important prognostic factor for patients with cervical carcinoma. However, the relationships between the number of positive nodes, site of metastases nodes, adjuvant therapy...

Authors: Xi Cheng, Shumo Cai, Ziting Li, Meiqin Tang, Muquan Xue and Rongyu Zang

In-situ and invasive carcinoma within a phyllodes tumor associated with lymph node metastases

Phyllodes tumors (cystosarcoma phyllodes) are uncommon lesions in the female breast. Rarely, the occurrence of carcinoma within a phyllodes tumor has been reported in the literature, but has never been associa...

Authors: Jeremy R Parfitt, Chris Armstrong, Frances O'Malley, Joan Ross and Alan B Tuck

Metallopanstimulin as a marker for head and neck cancer

Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-...

Authors: Brendan C Stack Jr, Christopher S Hollenbeak, Christopher M Lee, Frank R Dunphy, Val J Lowe and Paul D Hamilton

Seroma formation after surgery for breast cancer

Seroma formation is the most frequent postoperative complication after breast cancer surgery. We carried out a study to investigate the effect of various demographic, clinical and therapeutic variables on sero...

Authors: Esmat Hashemi, Ahmad Kaviani, Masoume Najafi, Mandana Ebrahimi, Homeira Hooshmand and Ali Montazeri

Pancreatic metastasis from gastric carcinoma: a case report

The pancreas is a rare but occasionally favored target for metastasis. Metastatic lesions in the pancreas have been described for various primary cancers, such as carcinomas of the lung, the breast, renal cell...

Authors: Moritz N Wente, Frank Bergmann, Boris E Fröhlich, Peter Schirmacher, Markus W Büchler and Helmut Friess

Open Access to essential health care information

Open Access publishing is a valuable resource for the synthesis and distribution of essential health care information. This article discusses the potential benefits of Open Access, specifically in terms of Low...

Authors: Christabel EL Stokes and Manoj Pandey

Ectopic paraesophageal mediastinal parathyroid adenoma, a rare cause of acute pancreatitis

The manifestation of primary hyperparathyroidism with acute pancreatitis is a rare event. Ectopic paraesophageal parathyroid adenomas account for about 5%–10% of primary hyperparathyroidism and surgical resect...

Authors: Christophoros N Foroulis, Sotirios Rousogiannis, Christos Lioupis, Dimitrios Koutarelos, Georgia Kassi and Athanassios Lioupis

Atrial fibrillation and survival in colorectal cancer

Survival in colorectal cancer may correlate with the degree of systemic inflammatory response to the tumour. Atrial fibrillation may be regarded as an inflammatory complication. We aimed to determine if atrial...

Authors: Stewart R Walsh, Kelly M Gladwish, Nicholas J Ward, Timothy A Justin and Neil J Keeling