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  1. Triple-negative breast cancer (TNBC) is a major subtype of breast cancer. Due to the lack of effective therapeutic targets, the prognosis is poor. In order to find an effective target, despite many efforts, th...

    Authors: Qianqian Yuan, Lewei Zheng, Yiqin Liao and Gaosong Wu

    Citation: World Journal of Surgical Oncology 2021 19:86

    Content type: Research

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  2. Effect of neoadjuvant chemotherapy (NAC) for pancreatic ductal adenocarcinoma (PDAC) has remained under investigation. We investigated its effect from a unique perspective and discussed its application.

    Authors: Yoshihiro Kurata, Takayuki Shiraki, Masanori Ichinose, Keiichi Kubota and Yasuo Imai

    Citation: World Journal of Surgical Oncology 2021 19:85

    Content type: Research

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  3. Colorectal cancer (CRC), the third most commonly diagnosed malignant carcinoma and the third most common cause of carcinoma-related mortality, continues to be a major international health problem. And approxim...

    Authors: An Shang, Shuang Wang, Yongping Yang, Liping Li, Zeyun Zhao, Donglin Li, Yu Guo and Min Wang

    Citation: World Journal of Surgical Oncology 2021 19:84

    Content type: Research

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  4. Gastric cancer is the fifth most common cancer worldwide, with an incidence of 6.72 per 100,000 people. Thirty-two percent of gastric cancer patients will live 5 years after diagnosis. Single-site metastasis i...

    Authors: Elizabeth Jacob, Levi Smucker, Ryan Crouse and Ayana Allard-Picou

    Citation: World Journal of Surgical Oncology 2021 19:83

    Content type: Case report

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  5. To reduce local recurrence risk, rectal washout (RW) is integrated in the total mesorectal excision (TME) technique when performing anterior resection (AR) for rectal cancer. Although RW is considered a safe p...

    Authors: Karl Teurneau-Hermansson, Rebecca Svensson Neufert, Pamela Buchwald and Fredrik Jörgren

    Citation: World Journal of Surgical Oncology 2021 19:82

    Content type: Research

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  6. There is still some debate as to whether transcatheter arterial chemoembolization (TACE) plus radiofrequency ablation (RFA) is better than TACE or RFA alone. This meta-analysis aimed to compare the efficacy an...

    Authors: Chuang Jiang, Gong Cheng, Mingheng Liao and Jiwei Huang

    Citation: World Journal of Surgical Oncology 2021 19:81

    Content type: Review

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  7. Many oncologists debate if lobular neoplasia (LN) is a risk factor or an obligatory precursor of more aggressive disease. This study has three aims: (i) describe the different treatment options (surgical resec...

    Authors: Jasna Metovic, Simona Osella Abate, Fulvio Borella, Elena Vissio, Luca Bertero, Giovanna Mariscotti, Manuela Durando, Rebecca Senetta, Ada Ala, Chiara Benedetto, Anna Sapino, Paola Cassoni and Isabella Castellano

    Citation: World Journal of Surgical Oncology 2021 19:80

    Content type: Research

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  8. Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we inve...

    Authors: Toshihisa Kimura, Tamotsu Togawa, Atsushi Iida, Sakon Noriki, Yasunori Sato and Takanori Goi

    Citation: World Journal of Surgical Oncology 2021 19:79

    Content type: Correspondence

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  9. Hepatocellular carcinoma (HCC) can grow in a mosaic pattern, often combined with various non-hepatocellular cells. However, HCC combined with a neuroendocrine carcinoma (NEC) component is rarely reported, and ...

    Authors: Akira Nakano, Kenichi Hirabayashi, Hiroshi Yamamuro, Taro Mashiko, Yoshihito Masuoka, Seiichiro Yamamoto, Soji Ozawa and Toshio Nakagohri

    Citation: World Journal of Surgical Oncology 2021 19:78

    Content type: Case report

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  10. The aim of this study was to investigate the safety and clinical usefulness of early oral feeding (EOF) after rectosigmoid resection with anastomosis for the treatment of primary ovarian cancer.

    Authors: Kazuyoshi Kato, Kohei Omatsu, Sanshiro Okamoto, Maki Matoda, Hidetaka Nomura, Terumi Tanigawa, Yoichi Aoki, Mayu Yunokawa and Hiroyuki Kanao

    Citation: World Journal of Surgical Oncology 2021 19:77

    Content type: Research

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  11. Lymphovascular invasion (LVI) is an important risk factor for prognosis of breast cancer and an unfavorable prognostic factor in node-negative invasive breast cancer patients. The purpose of this study was to ...

    Authors: Bo Bae Choi

    Citation: World Journal of Surgical Oncology 2021 19:76

    Content type: Research

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  12. Circular RNA (circRNA) plays an important role in regulating cell biological function and has been shown to be involved in cancer progression, including oral squamous cell carcinoma (OSCC). Circ-KIAA0907 has b...

    Authors: Wenjie Dong, Lei Zhao, Shiyang Zhang, Shijie Zhang and Hongyun Si

    Citation: World Journal of Surgical Oncology 2021 19:75

    Content type: Research

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  13. Inflammatory markers are measured following colorectal surgery to detect postoperative complications. However, the association of these markers preoperatively with subsequent postoperative course has not yet b...

    Authors: Sufana H. Alsaif, Ailín C. Rogers, Priscilla Pua, Paul T. Casey, Geoff G. Aherne, Ann E. Brannigan, Jurgen J. Mulsow, Conor J. Shields and Ronan A. Cahill

    Citation: World Journal of Surgical Oncology 2021 19:74

    Content type: Research

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  14. The incidence of adenocarcinoma of the esophagogastric junction (AEG) is rising every year; however, the mode of operation for Siewert II AEG is still controversial. Accumulating evidence has shown that transa...

    Authors: Yun Huang, Gang Liu, Xiumei Wang, Yan Zhang, Guijun Zou, Zhanwei Zhao, Zhen Cao, Huibin Zhao, Xinpu Yuan and Chaojun Zhang

    Citation: World Journal of Surgical Oncology 2021 19:73

    Content type: Research

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  15. Immediate breast reconstruction with skin-sparing (SSM) or nipple-sparing mastectomy (NSM) has become a common procedure. In this study, we evaluated the distance between breast tumor and skin in a series of p...

    Authors: Takaaki Fujii, Yuko Nakazawa, Misato Ogino, Sayaka Obayashi, Reina Yajima, Chikako Honda, Hideharu Nakamura, Takaya Makiguchi and Ken Shirabe

    Citation: World Journal of Surgical Oncology 2021 19:72

    Content type: Research

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  16. Epidemiological data on primary brain tumours (PBTs) are lacking due to the difficulty in case ascertainment among the population. Thus, we aimed to estimate mortality due to PBTs in China nationwide and the d...

    Authors: Bin Jiang, Hongmei Liu, Dongling Sun, Haixin Sun, Xiaojuan Ru, Jie Fu, Siqi Ge and Wenzhi Wang

    Citation: World Journal of Surgical Oncology 2021 19:71

    Content type: Research

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  17. Several aspects of the correlation between colon cancer and hemostatic markers are still unknown to many researchers in the field. In this study, we evaluated the association, if any, of preoperative platelet ...

    Authors: Berrin Papila Kundaktepe and Cigdem Papila

    Citation: World Journal of Surgical Oncology 2021 19:69

    Content type: Research

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  18. We present our 9-year consecutive case series of skull base chordomas and chondrosarcomas from a UK tertiary referral centre, discussing treatments offered and outcomes. This was carried out to improve underst...

    Authors: Christopher Metcalfe, Jameel Muzaffar, Kevin Kulendra, Paul Sanghera, Simon Shaw, Amjad Shad, Natarajan Saravanappa, Alessandro Paluzzi and Shahzada Ahmed

    Citation: World Journal of Surgical Oncology 2021 19:68

    Content type: Research

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  19. Hepatocellular carcinoma (HCC) is a common cancer and the leading cause is persistent hepatitis B virus (HBV) infection. We aimed to identify some core genes and pathways for HBV-related HCC.

    Authors: Mingxue Yu, Wenli Xu, Yusheng Jie, Jiahui Pang, Siqi Huang, Jing Cao, Jiao Gong, Xinhua Li and Yutian Chong

    Citation: World Journal of Surgical Oncology 2021 19:66

    Content type: Research

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  20. Synovial sarcoma (SS) is a rare soft tissue tumor. Among different anatomical locations where it can be found, gastric localization is a very uncommon one. Based on soft tissue sarcoma guidelines, complete tum...

    Authors: Matteo Rivelli, Eduardo Fernandes, Cristian Conti, Laura Bernardoni, Sara Pecori, Sara Cingarlini and Corrado Pedrazzani

    Citation: World Journal of Surgical Oncology 2021 19:65

    Content type: Case report

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  21. This paper aims to compare the efficacy and safety of recombinant human endostatin combined with chemotherapy in patients with squamous cell lung cancer (SqCLC).

    Authors: Li Feng, Zhicong Wang, Li Jing, Zhiguo Zhou, Shuai Shi, Ruoying Deng, Yibing Liu and Qingju Meng

    Citation: World Journal of Surgical Oncology 2021 19:64

    Content type: Research

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  22. Laparoscopic resection of giant hepatoblastoma (HB) in children has long been a subject of controversy. Here, a new procedure of two-stage laparoscopic resection of giant HB in infants was firstly reported and...

    Authors: Yaohao Wu, Lexiang Zeng, Ronglin Qiu, Jie Zhang, Jianhang Su, Minyi Liao and Xiaogeng Deng

    Citation: World Journal of Surgical Oncology 2021 19:63

    Content type: Research

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  23. Skeletal-related events (SREs) due to bone metastases (BM) significantly impact the morbidity and mortality of cancer patients. The present study sought to investigate clinicopathological characteristics, meta...

    Authors: Georg Herget, Babak Saravi, Eugenia Schwarzkopf, Mara Wigand, Norbert Südkamp, Hagen Schmal, Markus Uhl and Gernot Lang

    Citation: World Journal of Surgical Oncology 2021 19:62

    Content type: Research

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  24. Complete cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is the only curative treatment for pseudomyxoma peritonei (PMP) arising from the appendix. High peritoneal c...

    Authors: Bertrand Trilling, Alexandre Brind’Amour, Raphael Hamad, Jean-Francois Tremblay, Pierre Dubé, Andrew Mitchell and Lucas Sidéris

    Citation: World Journal of Surgical Oncology 2021 19:60

    Content type: Research

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  25. Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor originating from the secondary bile duct and its branch epithelium. Among primary liver tumors, the incidence of ICC is second only to hepatocellular ...

    Authors: Yongwei Zhang, Sihan Chen, Jun Li, Wei Dai and Yeben Qian

    Citation: World Journal of Surgical Oncology 2021 19:59

    Content type: Research

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  26. The associating liver partitioning and portal vein occlusion for staged hepatectomy (ALPPS) procedure is gaining interest because it brings hope to patients who cannot undergo radical surgical resection due to...

    Authors: Ming-Gen Hu, Jin Wang, Zhu-Zeng Yin and Rong Liu

    Citation: World Journal of Surgical Oncology 2021 19:58

    Content type: Case report

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  27. To compare perioperative and oncologic outcomes of open modified ureterosigmoidostomy urinary diversion (OMUUD) and intracorporeal modified ureterosigmoidostomy urinary diversion (IMUUD) following laparoscopic...

    Authors: Duo Zheng, Junyao Liu, Gongjin Wu, Shujun Yang, Chuang Luo, Tianci Du, Yao Luo, Junsheng Bao, Junqiang Tian, Zhiping Wang, Panfeng Shang and Zhongjin Yue

    Citation: World Journal of Surgical Oncology 2021 19:57

    Content type: Research

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  28. Growing evidence for the advantages of robotic pancreatoduodenectomy (RPD) has been demonstrated internationally. However, there has been no structured training program for RPD in Japan. Herein, we present the...

    Authors: Kosei Takagi, Yuzo Umeda, Ryuichi Yoshida, Takahito Yagi, Toshiyoshi Fujiwara, Amer H. Zureikat, Melissa E. Hogg and Bas Groot Koerkamp

    Citation: World Journal of Surgical Oncology 2021 19:55

    Content type: Technical innovations

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  29. This study aimed to investigate the short-term and oncological impact of the Endoscopic Surgical Skill Qualification System (ESSQS) by the Japan Society for Endoscopic Surgery on the operator performing laparo...

    Authors: Keisuke Kazama, Masakatsu Numata, Toru Aoyama, Yosuke Atsumi, Hiroshi Tamagawa, Teni Godai, Hiroyuki Saeki, Yusuke Saigusa, Manabu Shiozawa, Norio Yukawa, Munetaka Masuda and Yasushi Rino

    Citation: World Journal of Surgical Oncology 2021 19:53

    Content type: Research

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  30. Whether a sequential or concurrent regimen of anthracyclines and taxanes is superior for breast cancer is controversial. We compared the efficacy of two regimens in patients with operable breast cancer based o...

    Authors: Wanjing Chen, Qian Tu, Yanfei Shen, Kejun Tang, Mengying Hong and Yong Shen

    Citation: World Journal of Surgical Oncology 2021 19:52

    Content type: Research

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  31. Circular RNAs (circRNAs) are a class of endogenous single-strand RNA transcripts with crucial regulation in human cancers. The objective of this study is to investigate the role of circ_0082182 in CRC and its ...

    Authors: Ruijie Liu, Ping Deng, Yonglian Zhang, Yonglan Wang and Cuiping Peng

    Citation: World Journal of Surgical Oncology 2021 19:51

    Content type: Research

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  32. We invented a new antireflux anastomosis method for use in proximal gastrectomy for adenocarcinoma of the esophagogastric junction (AEG) and named it semi-embedded valve anastomosis (SEV). This study was condu...

    Authors: Yupeng Wu, Shihao Zhang, Liting Wang, Xuya Hu and Zhanxue Zhang

    Citation: World Journal of Surgical Oncology 2021 19:50

    Content type: Research

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  33. Histopathology is a crucial part of diagnosis and treatment guidance of colorectal cancer. In Denmark, it is not routine to biopsy during self-expandable metallic stent (SEMS) placement as a treatment option f...

    Authors: Sigrid Skov Bennedsgaard and Lene Hjerrild Iversen

    Citation: World Journal of Surgical Oncology 2021 19:48

    Content type: Review

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  34. Although completion lobectomy is the treatment of choice for local recurrence of non-small cell lung cancer after segmentectomy, few cases have been reported. We report four patients who underwent completion l...

    Authors: Shigeki Suzuki, Keisuke Asakura, Kyohei Masai, Kaoru Kaseda, Tomoyuki Hishida and Hisao Asamura

    Citation: World Journal of Surgical Oncology 2021 19:47

    Content type: Case report

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  35. Thrombocytopenia was reported both detrimental and advantageous to hepatocellular carcinoma (HCC). However, there is little evidence showing clearly the clinical value of preoperative thrombocytopenia on the s...

    Authors: Wei Peng, Chuan Li, Xiaoyun Zhang, Tianfu Wen and Zheyu Chen

    Citation: World Journal of Surgical Oncology 2021 19:46

    Content type: Research

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  36. Neoadjuvant chemotherapy is an important part of the comprehensive treatment of advanced gastric cancer (GC). The effect of neoadjuvant chemotherapy plays a key role in the prognosis of GC patients. Pathologic...

    Authors: Lin Jiang, Zhiqiang Ma, Xin Ye, Weiming Kang and Jianchun Yu

    Citation: World Journal of Surgical Oncology 2021 19:44

    Content type: Research

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  37. Accurate prediction of postoperative pulmonary function is important for ensuring the safety of patients undergoing radical resection for lung cancer. Dynamic perfusion digital radiography is an excellent and ...

    Authors: Jun Hanaoka, Makoto Yoden, Kazuki Hayashi, Takuya Shiratori, Keigo Okamoto, Ryosuke Kaku, Yo Kawaguchi, Yasuhiko Ohshio and Akinaga Sonoda

    Citation: World Journal of Surgical Oncology 2021 19:43

    Content type: Research

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  38. Xpert Bladder Cancer is a detection method developed in recent years, designed with the functions of integrating sample automatically, nucleic acid amplification, and target sequence detection. It is a urine a...

    Authors: Ye-Ling Liu, Xue-Lin Wang, Xiao-Hui Yang, Xiao-Huan Wu, Guo-Xin He, Li-Min Xie, Xun-Jie Cao and Xu-Guang Guo

    Citation: World Journal of Surgical Oncology 2021 19:42

    Content type: Research

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    The Correspondence to this article has been published in World Journal of Surgical Oncology 2021 19:237

  39. A peritumoral hypointense rim (PTHR) is sometimes observed around hepatocellular carcinoma (HCC) on T2*-weighted images (T2*WIs). We aimed to investigate the association between the PTHR and histopathologic fi...

    Authors: Yoshinori Tsukahara, Yukinori Okajima, Akira Yamada, Masanobu Momose, Takeshi Uehara, Akira Shimizu, Yuji Soejima and Yasunari Fujinaga

    Citation: World Journal of Surgical Oncology 2021 19:41

    Content type: Research

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  40. Intraoperative urinary collecting system entry (CSE) in robot-assisted partial nephrectomy (RAPN) may cause postoperative urinary leakage and extend the hospitalization. Therefore, identifying and firmly closi...

    Authors: Kenichi Nishimura, Yuichiro Sawada, Naoya Sugihara, Keisuke Funaki, Kanae Koyama, Terutaka Noda, Tetsuya Fukumoto, Noriyoshi Miura, Yuki Miyauchi, Tadahiko Kikugawa and Takashi Saika

    Citation: World Journal of Surgical Oncology 2021 19:40

    Content type: Research

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  41. The involvement of circular RNAs (circRNAs) in tamoxifen (TAM) resistance has been identified. Herein, we aimed to identify the role and novel mechanisms of hsa_circ_0025202 in tamoxifen resistance in breast c...

    Authors: Hongjuan Li, Qing Li and Shan He

    Citation: World Journal of Surgical Oncology 2021 19:39

    Content type: Research

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  42. Robotic and laparoscopic surgery for rectal cancer has been applied in the clinic for decades; nevertheless, which surgical approach has a lower rate of postoperative complications is still inconclusive. There...

    Authors: Bo Tang, Xiong Lei, Junhua Ai, Zhixiang Huang, Jun Shi and Taiyuan Li

    Citation: World Journal of Surgical Oncology 2021 19:38

    Content type: Research

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  43. Denosumab (XgevaTM) is a fully human antibody to RANK-Ligand, an important signal mediator in the pathogenesis of giant cell tumour of bone (GCTB). The use of denosumab in the treatment of GCTB has changed the wa...

    Authors: Wolfram Weschenfelder, John M. Abrahams and Luke J. Johnson

    Citation: World Journal of Surgical Oncology 2021 19:37

    Content type: Case report

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  44. Disease sites of female genital tract cancers of BRCA1/2-associated hereditary breast and ovarian cancer (HBOC) are less understood than non-hereditary cancers. We aimed to elucidate the disease site distribution...

    Authors: Takashi Mitamura, Masayuki Sekine, Masami Arai, Yuka Shibata, Momoko Kato, Shiro Yokoyama, Hiroko Yamashita, Hidemichi Watari, Ichiro Yabe, Hiroyuki Nomura, Takayuki Enomoto and Seigo Nakamura

    Citation: World Journal of Surgical Oncology 2021 19:36

    Content type: Correspondence

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