The use of adjuvant chemotherapy is not associated with recurrence or cancer-specific death following curative resection for stage III rectal cancer: a competing risks analysis

Table 6 Association between adjuvant chemotherapy and disease-free survival and between other variables independently associated with administration of AC and disease-free survival

	Category^a	Censored n = 131	Died of any cause or recurred n = 207	Bivariate hazard ratio (95% CI)	Wald P	Multivariable hazard ratio (95% CI)	Wald P
Adjuvant chemotherapy	No	30	100	REF	<0.001		0.048
Adjuvant chemotherapy	Yes	101	107	0.61 (0.46–0.80)		0.72 (0.52–0.99)	0.048
Year of resection	1995–1999	17	62	0.93 (0.83–1.04)	0.211	–	–
	2000–2004	29	54
	2005–2009	34	49
	2010–2014	20	25
	2015–2019	31	17
Age	< 75 years	117	150	REF	0.001		0.127
Age	≥ 75 years	14	57	1.69 (1.25–2.30)		1.32 (0.92–1.90)	0.127
Peripheral vascular disease	No	130	192	REF	0.004		0.081
Peripheral vascular disease	Yes	1	15	2.17 (1.28–3.69)		1.63 (0.94–2.84)	0.081
Intra-abdominal or pelvic abscess/haematoma	No	119	192	REF	0.824	–	–
Intra-abdominal or pelvic abscess/haematoma	Yes	12	15	0.94 (0.56–1.59)

Italicized P values indicate P significance at ≤ 0.05
RC rectal cancer, CI confidence interval
^aIn each cell, first line is the reference category coded 0, second line is the category of interest coded 1

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