Table 4 Relationship between TREM-1 and immune cell markers

CD8 + T cells

 CD8A

4.02 (1.78, 8.91)

4.83 (2.08, 11.86)

0.1521

 CD8B

1.51 (0.67, 3.78)

1.77 (0.65, 4.72)

0.2803

T cell (general)

 CD3D

5.91 (3.10, 12.27)

7.17 (3.22, 14.14)

0.0961

 CD3E

6.18 (3.15, 10.82)

6.88 (3.40, 13.22)

0.0758

 CD2

8.48 (4.24, 14.31)

9.87 (4.62, 18.40)

0.1377

B cells

 CD19

0.09 (0.05, 0.18)

0.12 (0.07, 0.32)

 < 0.0001

 CD79A

0.81 (0.40, 1.87)

1.10 (0.51, 3.62)

0.0009

Monocytes

 CD86

3.00 (1.77, 4.76)

5.29 (3.03, 7.78)

 < 0.0001

 CSF1R

14.07 (8.05, 21.92)

21.14 (12.12, 31.4)

 < 0.0001

TAM

 CCL2

25.13 (12.21,45.31)

33.27 (19.05,69.23)

 < 0.0001

 CD68

1.14 (0.60, 1.80)

1.50 (0.87, 2.48)

0.0001

 IL10

0.22 (0.11, 0.40)

0.45 (0.22, 0.84)

 < 0.0001

M1 macrophages

 NOS2

0.72 (0.39, 1.27)

0.65 (0.36, 1.12)

0.1412

 IRF5

4.61 (3.07, 6.16)

5.23 (3.69, 7.01)

0.0004

 PTGS2

0.84 (0.41, 1.76)

1.27 (0.61, 2.84)

 < 0.0001

M2 macrophages

 CD163

7.12 (3.47, 13.83)

14.36 (6.17, 24.42)

 < 0.0001

 VSIG4

7.90 (4.31, 13.08)

16.02 (7.40, 28.31)

 < 0.0001

 MS4A4A

5.50 (3.14, 9.09)

9.31 (4.81, 14.98)

 < 0.0001

Neutrophils

 CD66b

0.01 (0.00, 0.02)

0.01 (0.00, 0.02)

0.5579

 CD11b

2.88 (1.71, 4.19)

4.3 (2.63, 6.25)

 < 0.0001

 CCR7

0.9 (0.48, 1.48)

1.21 (0.65, 2.11)

 < 0.0001

NK cells

 KIR2DL1

0.09 (0.04, 0.17)

0.08 (0.03, 0.14)

0.066

 KIR2DL3

0.06 (0.03, 0.12)

0.05 (0.02, 0.10)

0.0506

 KIR2DL4

0.23 (0.10, 0.42)

0.25 (0.10, 0.51)

0.319

 KIR3DL1

0.07 (0.03, 0.15)

0.06 (0.02, 0.12)

0.0159

Dendritic cell

 HLA-DQB1

46.91 (21.45, 87.60)

53.96 (26.37, 90.47)

0.1491

 HLA-DPB1

118.82 (64.46, 193.7)

160.33 (90.71, 233.04)

0.0007

 HLA-DRA

757.63 (411.78, 1195.93)

986.52 (554.79, 1494.01)

0.0001

 BDCA-1

0.74 (0.40, 1.39)

0.94 (0.52, 1.49)

0.041

 BDCA-4

37.31 (21.78, 51.76)

37.64 (23.61, 50.55)

0.8289

 CD11c

2.98 (1.40, 4.91)

4.74 (2.47, 7.86)

 < 0.0001

Th1

 TBX21

0.85 (0.44, 1.37)

0.7 (0.37, 1.23)

0.9998

 STAT4

1.17 (0.66, 1.67)

1.24 (0.74, 1.79)

0.1184

 STAT1

33.78 (22.56, 50.48)

40.61 (27.01, 62.58)

0.0003

 INF-γ

0.19 (0.06, 0.49)

0.21 (0.07, 0.63)

0.3898

 TNF-α

0.30 (0.14, 0.58)

0.45 (0.25, 0.79)

 < 0.0001

Th2

 GATA3

1.42 (0.75, 3.86)

1.62 (0.86, 3.62)

0.3998

 STAT6

35.79 (28.29, 43.21)

36.03 (28.94, 41.36)

0.6576

 STAT5A

5.88 (4.40, 7.42)

6.7 (5.28, 8.34)

 < 0.0001

 IL13

0.01 (0.00, 0.02)

0.01 (0.00, 0.03)

0.0709

Tfh

 BCL6

10.75 (7.77, 14.61)

12.12 (8.86, 16.17)

0.0027

Th17

 STAT3

26.71 (21.49, 31.65)

29.45 (24.78, 34.8)

 < 0.0001

Tregs

 FOXP3

0.49 (0.26, 1.04)

0.77 (0.33, 1.69)

 < 0.0001

 CCR8

0.09 (0.02, 0.22)

0.14 (0.05, 0.35)

0.0007

 STAT5B

17.22 (14.61, 20.33)

16.4 (13.61, 19.01)

0.0053

 TGF-β

37.90 (24.11, 49.6)

38.57 (25.95, 52.5)

0.2186

T cell exhaustion

 PD-1

0.68 (0.35, 1.96)

1.17 (0.42, 2.59)

0.0051

 CTLA4

0.33 (0.13, 0.83)

0.56 (0.23, 1.30)

0.0002

 LAG3

1.02 (0.49, 2.72)

1.32 (0.60, 3.48)

0.071

 TIM-3

13.66 (5.61, 27.42)

14.81 (7.57, 27.71)

0.1604

 GZMB

3.02 (1.45, 5.06)

2.77 (1.47, 5.25)

0.8507