Table 4 Organ metastasis patterns in patients with neuroblastoma
From: Metastasis pattern and prognosis in children with neuroblastoma
Variable | N (%) |  ≤ 1 year, N (%) |  > 1 year, N (%) | P |
|---|---|---|---|---|
Total | 599 (100%) | 257 (%) | 342 (%) | – |
Bone metastasis only | 255 (42.6) | 71 (27.6) | 184 (53.8) |  < 0.001 |
Brain metastasis only | 1 (0.2) | 1 (0.4) | 0 (0.0) | 0.248 |
Liver metastasis only | 65 (10.9) | 58 (22.6) | 7 (2.0%) |  < 0.001 |
Lung metastasis only | 8 (1.3) | 3 (1.2) | 5 (1.5) | 0.756 |
Bone and brain | 29 (4.8) | 9 (3.5) | 20 (5.8) | 0.186 |
Bone and liver | 57 (9.5) | 34 (13.2) | 23 (6.7) | 0.007 |
Bone and lung | 17 (2.8) | 4 (1.6) | 13 (3.8) | 0.102 |
Brain and liver | 0 (0.0) | 0 (0.0) | 0 (0.0) | – |
Brain and lung | 0 (0.0) | 0 (0.0) | 0 (0.0) | – |
Liver and lung | 4 (0.7) | 4 (1.6) | 0 (0.0) | 0.021 |
Bone, brain and liver | 5 (0.8) | 2 (0.8) | 3 (0.9) | 0.895 |
Bone, brain and lung | 2 (0.3) | 1 (0.4) | 1 (0.3) | 0.839 |
Bone, liver and lung | 15 (2.5) | 9 (3.5) | 6 (1.8) | 0.175 |
Brain, liver and lung | 0 (0.0) | 0 (0.0) | 0 (0.0) | – |
Bone, brain, liver and lung | 2 (0.3) | 2 (0.8) | 0 (0.0) | 0.102 |
One site metastasis | 329 (54.9) | 133 (51.8) | 196 (57.3) | 0.176 |
Two-site metastases | 107 (17.9) | 51 (19.8) | 56 (16.4) | 0.272 |
Three-site metastases | 22 (3.7) | 12 (4.7) | 10 (2.9) | 0.261 |
Four-site metastases | 2 (0.3) | 2 (0.8) | 0 (0.0) | 0.102 |