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Table 3 Multivariate Cox proportional hazard regression model of OS and CSS

From: Metastasis pattern and prognosis in children with neuroblastoma

Variable

OS multivariate analysis

CSS multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Age (year)

 ≤ 1

Reference

–

Reference

–

 > 1

1.286 (0.926–1.787)

0.133

1.255 (0.882–1.786)

0.207

Primary site

 

0.282

 

0.221

 Adrenal

Reference

–

Reference

–

 Soft tissue

0.989 (0.561–1.744)

0.971

0.847 (0.450–1.597)

0.608

 Retroperitoneum

1.342 (0.681–2.642)

0.395

1.232 (0.587–2.584)

0.582

 Others

1.520 (0.940–2.457)

0.088

1.539 (0.917–2.582)

0.102

Laterality

 

0.003

 

0.017

 Unilateral

Reference

–

Reference

–

 Bilateral

1.088 (0.470–2.520)

0.843

1.123 (0.448–2.818)

0.804

 Unknown

0.407 (0.241–0.689)

0.001

0.440 (0.247–0.783)

0.005

Tumour size (cm)

 

0.013

 

0.006

 < 5

Reference

–

Reference

–

 5–10

1.948 (1.145–3.313)

0.014

2.200 (1.217–3.979)

0.009

 > 10

2.584 (1.465–4.560)

0.001

3.066 (1.642–5.725)

 < 0.001

 Unknown

1.999 (01.172–3.412)

0.011

2.044 (1.118–3.735)

0.020

Histology

    

 Neuroblastoma-NOS

Reference

–

Reference

–

 Ganglioneuroblastoma

0.904 (0.515–1.589)

0.727

0.943 (0.508–1.747)

0.851

Chemotherapy

   

–

 Yes

Reference

–

Reference

–

 No

0.623 (0.343–1.133)

0.121

0.451 (0.221–0.918)

0.028

Radiotherapy

    

 Yes

Reference

–

Reference

–

 No

0.998 (0.722–1.380)

0.990

0.941 (0.666–1.330)

0.731

Metastasis

    

 Yes

Reference

–

Reference

–

 No

0.250 (0.155–0.403)

 < 0.001

0.268 (0.161–0.447)

 < 0.001

  1. Abbreviations: CI, confidence interval; OS, overall survival; CSS, cancer-specific survival; NOS, not otherwise specified
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World Journal of Surgical Oncology

ISSN: 1477-7819

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