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Table 3 Univariable and multivariable analyses of overall survival before and after PSM

From: Safety and feasibility of laparoscopic liver resection for intrahepatic cholangiocarcinoma: a propensity score-matched study

Variables

Before PSM (n = 170)

After PSM (n = 105)

Univariable analysis

Multivariable analysis

Univariable analysis

Multivariable analysis

HR

95% Cl

P value

HR

95% Cl

p-value

HR

95% Cl

p-value

HR

95% Cl

p-value

Age

1.019

0.995–1.044

0.130

   

1.016

0.988–1.045

0.261

   

Gender, female vs. male

1.243

0.783–1.975

0.357

   

1.230

0.712–2.125

0.457

   

BMI

0.962

0.892–1.037

0.308

   

0.969

0.886–1.059

0.487

   

ASA score, high vs low

1.626

0.712–3.716

0.249

   

1.247

0.419–3.712

0.692

   

Cirrhosis, yes vs. no

1.405

0.783–2.523

0.254

   

1.308

0.635–2.694

0.466

   

Hepatitis B, yes vs. no

0.976

0.545–1.750

0.936

   

1.118

0.574–2.177

0.743

   

TBIL, high vs low

1.194

0.652–2.186

0.565

   

1.115

0.522–2.380

0.778

   

ALB, low vs high

1.176

0.738–1.875

0.495

   

1.024

0.591–1.774

0.933

   

PT, high vs low

1.556

0.833–2.906

0.165

   

1.118

0.475–2.633

0.799

   

PLT, low vs high

1.248

0.706–2.207

0.446

   

1.037

0.519–2.072

0.919

   

AFP, high vs low

0.844

0.306–2.323

0.742

   

1.030

0.369–2.877

0.955

   

CEA, high vs low

2.767

1.696–4.515

< 0.001

0.969

0.492–1.908

0.927

2.875

1.589–5.202

< 0.001

1.359

0.525–3.517

0.527

CA19-9, high vs low

2.772

1.543–4.978

0.001

1.933

0.903–4.137

0.090

3.905

1.917–7.955

< 0.001

2.838

1.237–6.511

0.014

CA12-5, high vs low

3.173

1.919–5.247

< 0.001

3.018

1.438–6.332

0.003

3.060

1.660–5.639

< 0.001

2.716

1.366–5.401

0.004

Child–Pugh, high vs low

1.597

0.839–3.040

0.154

   

0.923

0.223–3.827

0.912

   

Surgical operation, open vs laparoscopic

1.692

1.036–2.762

0.035

1.043

0.523–2.080

0.905

1.700

0.964–2.997

0.067

1.618

0.707–3.705

0.255

Anatomical liver resection, yes vs. no

1.539

0.857–2.764

0.149

   

1.707

0.854–3.411

0.130

   

Extent of resection, major vs minor

1.194

0.994–1.433

0.058

0.964

0.744–1.248

0.779

1.330

1.063–1.663

0.012

1.038

0.731–1.475

0.834

Lymphadenectomy ≥ 6, yes vs. no

1.790

1.126–2.844

0.014

0.978

0.515–1.858

0.947

1.700

0.974–2.970

0.062

1.030

0.456–2.329

0.943

Operation time

1.002

1.000–1.004

0.015

1.001

0.999–1.004

0.406

1.003

1.001–1.005

0.015

1.003

0.999–1.006

0.184

Blood transfusion, yes vs. no

1.591

1.003–2.523

0.049

0.681

0.326–1.426

0.309

1.378

0.797–2.381

0.251

0.553

0.221–1.383

0.205

Blood loss

1.000

1.000–1.000

0.296

   

1.000

1.000–1.000

0.547

   

Tumor sizes

1.048

0.953–1.153

0.334

   

1.017

0.906–1.142

0.770

   

No. of tumors, multiple vs solitary

1.863

1.066–3.257

0.029

1.371

0.653–2.880

0.405

1.827

0.855–3.902

0.120

2.038

0.605–6.865

0.250

Clavien-Dindo classification, major vs minor/none

1.463

0.813–2.633

0.204

   

0.563

0.202–1.567

0.271

   

Postoperative hospital stay

1.024

1.011–1.037

< 0.001

1.023

1.003–1.043

0.026

1.033

1.015–1.051

 < 0.001

1.034

1.013–1.056

0.002

Tumor differentiation, low vs. high

1.108

0.789–1.557

0.554

   

1.163

0.774–1.748

0.466

   

Lymph node metastasis, yes vs. no

2.552

1.551–4.197

< 0.001

1.334

0.651–2.733

0.431

2.596

1.421–4.743

0.002

1.266

0.500–3.209

0.619

Nerve invasion, yes vs. no

1.685

0.955–2.973

0.072

0.787

0.359–1.727

0.550

1.873

0.896–3.914

0.095

0.852

0.262–2.766

0.790

R0 resection, yes vs. no

0.504

0.240–1.060

0.071

0.767

0.322–1.828

0.549

0.279

0.122–0.640

0.003

0.536

0.160–1.795

0.312