Table 4 Subgroup analysis of DFS

PVI

Without PVI

4

DFS^a

0.66

0.53–0.82

0%

4

1y-DFS

1.14

0.98–1.32

71%

4

3y-DFS

1.31

0.981.77

72%

3

5y-DFS

0.94

0.59–1.49

56%

With PVI

3

DFS^a

0.38

0.21–0.69

63%

3

1y-DFS

2.10

1.03–4.29

68%

3

3y-DFS

2.33

0.75–7.30

70%

3

5y-DFS

2.37

0.62–9.08

47%

Chemotherapy

Cisplatin based

6

DFS^a

0.71

0.52–0.90

20%

6

1y-DFS

1.15

0.98–1.35

52%

5

3y-DFS

1.05

0.88–1.26

7%

4

5y-DFS

0.94

0.59–1.50

45%

Interferon + 5-FU

2

DFS^a

0.30

0–0.69

41%

2

1y-DFS

2.40

1.02–5.65

52%

2

3y-DFS

2.18

0.32–14.76

79%

1

5y-DFS

16.80

1.05–268.35

/

Oxaliplatin based

2

DFS^a

0.59

0.43–0.75

0%

2

1y-DFS

1.24

1.08–1.43

0%

2

3y-DFS

1.72

1.32–2.24

0%

1

5y-DFS

1.46

0.61–3.48

/

MVI

With MVI

5

DFS^a

0.73

0.60–0.88

30%

5

1y-DFS

1.24

1.12–1.38

0%

4

3y-DFS

1.57

1.27–1.94

25%

2

5y-DFS

1.19

0.79–1.81

0%